Differences in plasma prolactin levels in patients with schizophrenia treated on monotherapy with five second-generation antipsychotics.
Differences in plasma prolactin levels in patients with schizophrenia treated on monotherapy with five second-generation antipsychotics.
复制标题
接受五种第二代抗精神病药物单一疗法的精神分裂症患者血浆催乳素水平的差异。
DOI：
10.1016/j.schres.2012.12.027
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Someya T.
中科院分区：
文献类型：
--
作者：
Suzuki Y;Sugai T;Fukui N;Watanabe J;Ono S;Tsuneyama N;Saito M;Someya T.
虽然第二代抗精神病药（SGAs）的特点是较少的催乳素（PRL）相关的副作用相比，第一代抗精神病药，SGAs对血浆PRL水平的详细影响仍然不清楚。我们检查了268名接受奥氮平（OLZ）、利培酮（RIS）、阿立哌唑（阿普）、奎硫平（QTP）或哌罗螺酮（PER）治疗的精神分裂症患者血浆催乳素水平的差异。受试者接受稳定剂量的OLZ、RIS、阿普、QTP或PER单药治疗≥ 3周，并抽取空腹血液样本检测血浆PRL水平。5组SGA患者血浆PRL水平中位数在所有患者（P<0.001）、男性患者（P<0.001）和女性患者（P<0.001）之间差异均有统计学意义。多元逐步回归分析显示，阿普治疗有助于降低血浆PRL水平，而女性、RIS、OLZ和氯丙嗪等效剂量有助于升高血浆PRL水平。RIS组血浆PRL水平的中位数是OLZ组的2倍，但无统计学意义。本研究中，OLZ对血浆PRL水平有相当大的影响，与RIS相似，而PER对血浆PRL水平无影响，与QTP相似。需要进一步的研究来阐明SGAs之间血浆PRL水平的差异。
Although second-generation antipsychotics (SGAs) are characterized by fewer prolactin (PRL)-related side effects compared with first-generation antipsychotics, the detailed effects of SGAs on the plasma PRL levels still remain unclear. We examined the differences in plasma PRL levels among 268 patients treated for schizophrenia with olanzapine (OLZ), risperidone (RIS), aripiprazole (ARP), quetiapine (QTP), or perospirone (PER). The participants had received antipsychotic monotherapy with stable doses of OLZ, RIS, ARP, QTP, or PER for ≥3weeks, and fasting blood samples were drawn to examine plasma PRL levels. The differences in median plasma PRL levels in all (P<0.001), male (P<0.001) and female patients (P<0.001) among the five SGA groups were statistically significant. A stepwise multiple regression analysis showed that ARP treatment was found to contribute to lower plasma PRL level, while female sex, RIS, OLZ and chlorpromazine equivalent dose were found to contribute to a higher plasma PRL level. The median value of plasma PRL level in the RIS group was twice as much compared with that in the OLZ group, although this was not statistically significant. In this study, OLZ had a considerable effect on plasma PRL level, similar to RIS, while PER did not affect plasma PRL levels, similar to QTP. Further studies are needed to clarify the differences in plasma PRL levels among SGAs.