Design Study of an Ultrahigh Resolution Brain SPECT System Using a Synthetic Compound-Eye Camera Design With Micro-Slit and Micro-Ring Apertures.
Design Study of an Ultrahigh Resolution Brain SPECT System Using a Synthetic Compound-Eye Camera Design With Micro-Slit and Micro-Ring Apertures.
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DOI：
10.1109/tmi.2021.3096920
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发表时间：
2021-12
影响因子：
10.6
通讯作者：
Meng LJ
中科院分区：
文献类型：
--
作者：
Zannoni EM;Yang C;Meng LJ
在本文中，我们讨论了基于球形合成复眼 (SCE) 伽马相机设计的大脑 SPECT 成像系统（称为 HelmetSPECT 系统）的设计研究。该设计采用大量（约 500 个）半导体探测器模块，每个模块都耦合到一个具有非常窄开口的孔径，用于高分辨率 SPECT 成像应用。在这项研究中，我们证明这种新颖的系统设计可以提供出色的空间分辨率、非常高的灵敏度和丰富的角度采样，而无需在临床相关视场（FOV）上扫描运动。这些特性使得所提出的 HelmetSPECT 系统对于癫痫患者癫痫发作期间的动态成像具有吸引力。在发作期 SPECT 中，通常没有关于癫痫发作发生位置的先验信息，动态 SPECT 图像的成像分辨率和定量准确性将为癫痫发作分期和完善后续手术干预计划提供关键信息。我们报告了使用非传统孔径（例如微环和微缝）和传统阁楼孔孔径的类似系统几何形状的性能评估和比较。我们证明，超高分辨率成像探测器、SCE 伽马相机设计以及微环和微缝孔径的组合将为未来超高分辨率临床 SPECT 成像系统提供一种有趣的方法，而无需牺牲系统灵敏度和 FOV。
In this paper, we discuss the design study for a brain SPECT imaging system, referred to as the HelmetSPECT system, based on a spherical synthetic compound-eye (SCE) gamma camera design. The design utilizes a large number ( ~500) of semiconductor detector modules, each coupled to an aperture with a very narrow opening for high-resolution SPECT imaging applications. In this study, we demonstrate that this novel system design could provide an excellent spatial resolution, a very high sensitivity, and a rich angular sampling without scanning motion over a clinically relevant field-of-view (FOV). These properties make the proposed HelmetSPECT system attractive for dynamic imaging of epileptic patients during seizures. In ictal SPECT, there is typically no prior information on where the seizures would happen, and both the imaging resolution and quantitative accuracy of the dynamic SPECT images would provide critical information for staging the seizures outbreak and refining the plans for subsequent surgical intervention.We report the performance evaluation and comparison among similar system geometries using non-conventional apertures, such as micro-ring and micro-slit, and traditional lofthole apertures. We demonstrate that the combination of ultrahigh-resolution imaging detectors, the SCE gamma camera design, and the micro-ring and micro-slit apertures would offer an interesting approach for the future ultrahigh-resolution clinical SPECT imaging systems without sacrificing system sensitivity and FOV.