A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia
A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia
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DOI：
10.1016/j.psychres.2013.12.009
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发表时间：
2014-02-28
影响因子：
11.3
通讯作者：
Iyo, Masaomi
中科院分区：
文献类型：
--
作者：
Niitsu, Tomihisa;Ishima, Tamaki;Iyo, Masaomi
一项荟萃分析研究报告称，血清脑源性神经营养因子(BDNF)水平可作为精神分裂症的潜在生物标志物。然而，当时，由于抗体特异性有限，商业上可用的人类ELISA试剂盒无法区分前BDNF(前体BDNF)和成熟的BDNF。在这里，我们使用新的酶联免疫试剂盒，检测了精神分裂症患者血清中成熟BDNF和基质金属蛋白酶-9(MMP9)的水平，基质金属蛋白酶-9可将前体BDNF转化为成熟的BDNF。纳入63例慢性精神分裂症患者和52例年龄、性别匹配的健康对照。使用简明精神病学评定量表、阴性症状评定量表(SANS)和神经心理测试对患者进行评估。血清成熟脑源性神经营养因子和基质金属蛋白酶-9水平在患者和对照组之间均无差异。在男性亚组中，吸烟患者的血清MMP9水平高于不吸烟患者，但在男性对照组和女性亚组中未观察到这种情况。在患者中，血清成熟BDNF水平与SANS总分和韦氏成人智力量表(WAIS-R)的信息分测验得分相关，而血清基质金属蛋白酶-9水平与吸烟和类别流利性得分相关。这些发现表明，成熟的脑源性神经营养因子和基质金属蛋白酶-9都不是适合精神分裂症的生物标记物，尽管还需要使用大样本进行进一步的研究。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
A meta-analysis study reported serum brain-derived neurotrophic factor (BDNF) levels as a potential biomarker for schizophrenia. However, at the time, commercially available human ELISA kits were unable to distinguish between pro-BDNF (precursor BDNF) and mature BDNF, because of limited antibody specificity. Here, we used new ELISA kits, to examine serum levels of mature BDNF and matrix metalloproteinase-9 (MMP-9), which converts pro-BDNF to mature BDNF in schizophrenia. Sixty-three patients with chronic schizophrenia and 52 age- and sex-matched healthy controls were enrolled. Patients were evaluated using the Brief Psychiatry Rating Scale, the Scale for the Assessment of Negative Symptoms (SANS) and neuropsychological tests. Neither serum mature BDNF nor MMP-9 levels differed between patients and controls. In male subgroups, serum MMP-9 levels of smoking patients were higher than those of non-smoking patients, but this was not observed in male controls or the female subgroup. In patients, serum mature BDNF levels were associated with SANS total scores and the Information subtest scores of the Wechsler Adult Intelligence Scale Revised (WAIS-R), while serum MMP-9 levels were associated with smoking and category fluency scores. These findings suggest that neither mature BDNF nor MMP-9 is a suitable biomarker for schizophrenia, although further studies using large samples are needed. (C) 2013 Elsevier Ireland Ltd. All rights reserved.