The surface glycoproteins of hantaviruses
The surface glycoproteins of hantaviruses
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DOI：
10.1016/j.coviro.2021.07.009
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发表时间：
2021-08-19
影响因子：
5.9
通讯作者：
Rey, Felix A.
中科院分区：
文献类型：
--
作者：
Guardado-Calvo, Pablo;Rey, Felix A.
汉坦病毒是啮齿动物传播的病毒，分布于世界各地，通过空气传播，并能够在人与人之间传播。它们在啮齿动物宿主中保持无症状的持续感染，但它们对人类的溢出产生与高死亡率相关的肾或肺综合征。汉坦病毒颗粒是有脂质包膜的，并显示由两种糖蛋白Gn和Gc组成的四方刺突构成的特征性表面晶格。这些粒子的多晶性阻碍了低温电子显微镜获得详细结构信息的努力，只有通过使用X射线晶体学和低温电子断层扫描的组合，才有可能建立表面晶格的原子模型。在这里，我们回顾了这些结构努力以及这些研究强调的汉坦病毒和甲病毒之间意想不到的进化关系。
Hantaviruses are rodent-borne viruses distributed worldwide, transmitted through the air and with the ability to spread from person to person. They maintain a non-symptomatic persistent infection in their rodent hosts, but their spillover to humans produces a renal or pulmonary syndrome associated with high fatality rates. Hantavirus particles are lipid-enveloped and display a characteristic surface lattice built up of tetragonal spikes composed of two glycoproteins, Gn and Gc. The pleomorphism of these particles has hindered cryo-EM efforts to obtain detailed structural information and only by using a combination of X-ray crystallography and cryo-electron tomography it was possible to build an atomic model of the surface lattice. Here we review these structural efforts and the unanticipated evolutionary relations between hantaviruses and alphaviruses highlighted by these studies.