Mid-pregnancy maternal plasma levels of interleukin 2, 6, and 12, tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor and spontaneous preterm delivery
Mid-pregnancy maternal plasma levels of interleukin 2, 6, and 12, tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor and spontaneous preterm delivery
复制标题
DOI：
10.1080/00016340701515423
复制
发表时间：
2007-01-01
影响因子：
4.3
通讯作者：
Thorsen, Poul
中科院分区：
文献类型：
--
作者：
Curry, Allison E.;Vogel, Ida;Thorsen, Poul
背景很少有研究调查炎症和自发性早产（sPTD）之间的关系，在早产前的妇女。作者研究了妊娠中期血浆细胞因子水平是否与sPTD相关，以及相关性是否因母亲年龄、体重指数、既往早产或妊娠而异。方法.这项病例对照研究是在丹麦国家出生队列中进行的，这是一个1997年至2002年期间有101，042例妊娠的妇女队列。在这项研究中，有61名妇女在24 - 29周分娩，278名妇女在30 - 33周分娩，334名妇女在34 - 36周分娩，1,125名妇女在≥ 37周分娩。采用多重流式细胞术检测孕25周孕妇血浆白细胞介素（IL）-2，IL-6，肿瘤坏死因子（TNF）-α，干扰素（IFN）-γ和粒细胞-巨噬细胞集落刺激因子（GM-CSF）。结果对于IL-2、TNF-α和GM-CSF，水平>第75或>第90百分位数的妇女比例在分娩时的胎龄之间没有差异。IFN-γ>第90百分位数与30 - 33周分娩风险增加相关（粗比值比（cOR）：1.56; 95%置信区间（CI）：1.07 - 2.30），而IFN-γ>第75百分位数和IL-6 >第75百分位数与34 - 36周分娩风险增加相关（cOR：1.32; 95% CI：1.01 - 1.73）;调整混杂因素后估计值变化不大。母体因素未对效应测量值进行修改。结论妊娠中期血浆IL-2、TNF-alpha和GM-CSF升高似乎与sPTD风险增加无关，而IFN-γ和IL-6水平升高与中度和晚期sPTD弱相关。使用中期妊娠细胞因子预测自发性早产的价值似乎有限。
Background. Few studies have investigated the relationship between inflammation and spontaneous preterm delivery ( sPTD) in women before preterm labour. The authors examine whether mid-pregnancy plasma cytokine levels are associated with sPTD, and whether associations vary by maternal age, body mass index, prior preterm delivery, or gravidity. Methods. This case-control study was nested within the Danish National Birth Cohort, a cohort of women with 101,042 pregnancies from 1997 to 2002. Included in this study are 61 women delivering at 24 - 29 weeks, 278 delivering at 30 - 33 weeks, 334 delivering at 34 - 36 weeks, and 1,125 delivering at >= 37 weeks. Maternal plasma interleukin ( IL)-2, IL-6, tumor necrosis factor ( TNF)-alpha, interferon ( IFN)-gamma, and granulocyte-macrophage colony-stimulating factor ( GM-CSF) at 25 weeks' gestation were measured using multiplex flow cytometry. Results. For IL-2, TNF-alpha, and GM-CSF, the proportion of women with levels > 75th or > 90th percentile did not differ by gestational age at delivery. IFN-gamma > 90th percentile was associated with an increased risk of delivering at 30 - 33 weeks ( crude odds ratio ( cOR): 1.56; 95% confidence interval ( CI): 1.07 - 2.30), while IFN-gamma > 75th percentile and IL-6 > 75th percentile were associated with an increased risk of delivering at 34 - 36 weeks ( cOR: 1.32; 95% CI: 1.01 - 1.73); estimates changed little after adjusting for confounders. There was no effect-measure modification by maternal factors. Conclusion. Elevated mid-pregnancy plasma IL-2, TNF-alpha, and GM-CSF did not appear to be associated with an increased risk of sPTD, while elevated IFN-gamma and IL-6 levels were weakly associated with moderate and late sPTD. The value of using mid-pregnancy cytokines in predicting spontaneous preterm delivery appears limited.