Mitochondrial and Cellular Metabolism in Experimental Hyperoxaluric Nephrolithiasis
Mitochondrial and Cellular Metabolism in Experimental Hyperoxaluric Nephrolithiasis
复制标题
实验性高草酸尿肾结石的线粒体和细胞代谢
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
C. Scheid
中科院分区：
文献类型：
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作者：
M. Menon;T. Strzelecki;B. McGraw;C. Scheid
我们推测草酸钙肾结石是两种不同过程的结果--肾小管细胞功能障碍和钙/草酸高排泄。为了验证这一假设，我们通过评估以严重高草酸尿症为特征的肾结石动物模型的细胞和线粒体功能，研究了草酸超载本身是否会导致细胞紊乱。
We have speculated that calcium-oxalate nephrolithiasis results from a combination of two distinct processes - tubular cell dysfunction and calcium/oxalate hyper-excretion. To test this hypothesis, we investigated whether oxalate overload by itself would give rise to cellular derangements by assessing cellular and mitochondrial function in an animal model of nephrolithiasis characterized by profound hyperoxaluria.