Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)
Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)
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DOI：
10.1128/jvi.75.10.4843-4853.2001
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发表时间：
2001-05-01
影响因子：
5.4
通讯作者：
Zeichner, S
中科院分区：
文献类型：
--
作者：
Paulose-Murphy, M;Ha, NK;Zeichner, S
人类疱疹病毒 8 型 (HHV-8) 是一种与卡波西肉瘤、原发性渗出性淋巴瘤和卡斯尔曼病有关的伽玛疱疹病毒，编码几种具有重要致病性的细胞同源物。为了定义 HHV-8 转录程序，使用从诱导进行裂解性复制的潜伏感染体腔淋巴瘤 1 细胞中获得的 RNA 来查询包含几乎所有已知病毒开放阅读框的定制 HHV-8 DNA 微阵列。病毒基因表达模式为了解 HHV-8 的复制和致病策略提供了见解。
Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV-8.