Immunosenescence and herd immunity: with an ever-increasing aging population do we need to rethink vaccine schedules?
Immunosenescence and herd immunity: with an ever-increasing aging population do we need to rethink vaccine schedules?
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DOI：
10.1586/erv.11.187
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发表时间：
2012-02-01
影响因子：
6.2
通讯作者：
Aspinall, Richard
中科院分区：
文献类型：
--
作者：
Lang, Pierre Olivier;Aspinall, Richard
疫苗接种是一种强有力的公共卫生工具，在保护弱势群体免受特定感染方面具有巨大的益处。此外，除了对接种疫苗的个人的直接好处外，在社区一级的保护的间接影响也得到了证明，并被称为“群体免疫”。预测的人口结构向不断增加的老龄化人口转变，以及有证据表明老年人产生的疫苗应答低于最佳水平，这提出了重新思考疫苗接种时间表的问题。本文提供的证据表明，即使群体免疫可能是一种选择，以间接保护老龄化和老年人的人口，在不久的将来，最高的优先事项必须是了解如何在老年人的疫苗反应可以得到改善，打破公众，文化，社会和政治的障碍，接种疫苗，并打击反接种运动，抑制终身免疫计划的全球传播。
Vaccination is a powerful public health tool that has been of tremendous benefit in protecting vulnerable populations from specific infections. Moreover, in addition to the direct benefits to vaccinated individuals, the indirect effects of protection at the community level have also been demonstrated and termed 'herd immunity'. The predicted demographic shift in the population landscape towards an ever-increasing aging population and the evidence suggesting that older individuals produce less-than-optimal vaccine responses have raised the question of rethinking vaccine schedules. This article provides evidence that even if herd immunity might be an option to indirectly protect the aging and aged adult population, the highest priorities for the near future must be to understand how vaccine responses in older individuals can be improved, to break down the public, cultural, societal and political barriers to vaccination and to counter the antivaccination movement that inhibits the worldwide spread of lifelong immunization programs.