Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer.
Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer.
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DOI：
10.1677/erc-08-0036
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发表时间：
2008-12
影响因子：
3.9
通讯作者：
Fagin JA
中科院分区：
文献类型：
--
作者：
Ryder M;Ghossein RA;Ricarte-Filho JC;Knauf JA;Fagin JA
甲状腺癌浸润肿瘤相关巨噬细胞（tam），但其在癌症进展中的作用尚不清楚。本研究的目的是表征高分化（WDTC）、低分化（PDTC）和间变性甲状腺癌（ATC）中TAM的密度，并将TAM密度与临床病理参数联系起来。采用巨噬细胞特异性标志物对WDTC （n=33）、PDTC （n=37）和ATC （n=20）的组织微阵列切片进行免疫组化。采用电子病历收集临床和病理资料。PDTC患者随访时间为0 ~ 12年。33例WDTC中有9例（27%）、20/37PDTC（54%）和19/20 ATC（95%）的CD68+ tam密度增加（=/ bbb10 / 0.28 mm2） （p = 0.03, WDTC vs PDTC; p < 0.0001）。WDTC与ATC；p < 0.002, PDTC vs. ATC)。与低密度的TAMs相比，PDTC中TAMs的增加与囊膜侵犯（p = 0.034）、甲状腺外展（p = 0.009）和癌症相关生存率降低（p = 0.009）相关。总之，晚期甲状腺癌中tam的密度增加。PDTC中高密度tam的存在与侵袭和癌症相关生存率降低相关。这些结果表明tam可能促进肿瘤进展。由于针对甲状腺肿瘤细胞特异性靶点的新疗法正在测试中，tam作为甲状腺癌行为的潜在调节剂的潜在作用将需要考虑。
Thyroid cancers are infiltrated with tumor associated-macrophages (TAMs), yet their role in cancer progression is not known. The objectives of this study were to characterize the density of TAMs in well-differentiated (WDTC), poorly-differentiated (PDTC) and anaplastic thyroid cancers (ATC) and to correlate TAM density with clinicopathologic parameters. Immunohistochemistry was performed on tissue microarray sections from WDTC (n=33), PDTC (n=37) and ATC (n=20) using macrophage specific markers. Electronic medical records were used to gather clinical and pathologic data. Follow-up information of PDTC patients was available for 0−12 years. Nine of 33 WDTC (27%), 20/37PDTC (54%) and 19/20 ATC (95%) had an increased density of CD68+ TAMs (=/>10 per 0.28 mm2) (p = 0.03, WDTC vs. PDTC; p < 0.0001. WDTC vs. ATC; p < 0.002, PDTC vs. ATC). Increased TAMs in PDTC was associated with capsular invasion (p = 0.034), extrathyroidal extension (p = 0.009) and decreased cancer-related survival (p = 0.009) compared to PDTC with a low density of TAMs. In conclusion, the density of TAMs is increased in advanced thyroid cancers. The presence of a high density of TAMs in PDTC correlates with invasion and decreased cancer-related survival. These results suggest that TAMs may facilitate tumor progression. As novel therapies directed against thyroid tumor cell-specific targets are being tested, the potential role of TAMs as potential modulators of the thyroid cancer behavior will need to be considered.