Rapid down-regulation of thyroid hormones in acute myocardial infarction - Is it cardioprotective in patients with angina?
Rapid down-regulation of thyroid hormones in acute myocardial infarction - Is it cardioprotective in patients with angina?
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DOI：
10.1001/archinte.162.12.1388
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发表时间：
2002-06-24
影响因子：
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通讯作者：
Ahnve, S
中科院分区：
文献类型：
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作者：
Friberg, L;Werner, S;Ahnve, S
背景：在任何原因导致的严重疾病中，甲状腺激素系统可能会下调。这对急性心肌梗死（AMI）患者有何影响在很大程度上尚不清楚。
目的：研究急性心肌梗死期间甲状腺激素血清水平的变化及其与心脏功能和预后的关系。
方法：对47例甲状腺功能正常的急性心肌梗死患者在发病后的前5天以及6周和12周后进行前瞻性研究。所有分析均采用从疼痛发作开始的时间。
结果：甲状腺激素系统迅速下调，在症状出现后24至36小时变化最大。激素总三碘甲状腺原氨酸（T - 3）的平均水平下降了19%（P = 0.02），无活性代谢产物反T - 3（rT₃）水平上升了22%（P = 0.01），促甲状腺激素水平下降了51%（P
（最后一个P后面似乎内容不完整）
Background: In severe illness of any cause, downregulation of the thyroid hormone system may occur. How this affects patients with acute myocardial infarction (AMI) is largely unknown.Objective: To investigate changes in serum levels of the thyroid hormones during AMI and their association with cardiac function and outcome.Methods: Forty-seven consecutive euthyroid patients,with AMI were studied prospectively during the First 5 days and again 6 and 12 weeks later. Time from pain onset was used in all analyses.Results: The thyroid hormone system was rapidly down-regulated with maximal changes 24 to 36 hours after onset of symptoms. The mean level of the hormone total triioclothyronine (T-3) decreased 19% (P=.02), the inactive metabolite reverse T-3 (rT(3)) levels increased 22% (P=.01), and thyrotropin levels declined 51% (P