Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis.
Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis.
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发表时间：
2022
影响因子：
1.4
通讯作者：
Lingmin Liao;Zhenmei Gu;Ming Fang;Gong-Ji Yao;Long Huang
中科院分区：
文献类型：
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作者：
Lingmin Liao;Zhenmei Gu;Ming Fang;Gong-Ji Yao;Long Huang
背景宫颈小细胞癌（SCCC）是一种罕见的疾病，对其分子标志物知之甚少。核柔蛋白α2 （KPNA2）已在多种恶性肿瘤中得到证实。我们的目的是确定KPNA2水平是否能预测SCCC患者的临床结果。方法采用免疫组化方法检测62例SCCC肿瘤组织中KPNA2的表达。H-score评价染色结果。分析KPNA2表达水平与临床特征及预后的相关性。结果55例SCCC患者肿瘤组织中检测到KPNA2表达（55/62,89%）。与低KPNA2表达相比，高KPNA2表达与国际妇产联合会分期（P=0.035）、肿瘤大小（P=0.019）、总生存期（P=0.008）和无病生存期（P=0.004）显著相关。多因素分析显示，KPNA2表达水平（P=0.037）和肿瘤大小（P=0.046）是影响OS预后的独立因素。结论KPNA2可能是SCCC的分子标志物和预后指标。
BACKGROUND Cervical small cell carcinoma (SCCC) is uncommon and little is known about its molecular markers. Karyopherin α2 (KPNA2) has been demonstrated in a variety of malignancies. Our objective was to determine whether the KPNA2 level is predictive of clinical outcome in patients with SCCC. METHODS We detected KPNA2 expression by immunohistochemistry in SCCC tumors from 62 patients. The staining results were evaluated by H-score. The correlation among KPNA2 expression level, clinical characteristics, and prognosis was analyzed. RESULTS KPNA2 expression was detected in tumor tissue from 55 patients with SCCC (55/62, 89%). High KPNA2 expression correlated significantly with International Federation of Gynecology and Obstetrics staging (P=0.035), tumor size (P=0.019), poorer overall survival (OS) (P=0.008), and poorer disease-free survival (P=0.004) compared to low KPNA2 expression. Multivariate analysis showed that KPNA2 expression level (P=0.037) and tumor size (P=0.046) were independent prognostic factors of OS. CONCLUSIONS KPNA2 may be a molecular marker and indicator of prognosis in SCCC.