Is there a common dopaminergic basis of time perception and reaction time?
Is there a common dopaminergic basis of time perception and reaction time?
复制标题
时间感知和反应时间是否存在共同的多巴胺能基础？
作者：
Thomas Rammsayer
在一项安慰剂对照、双盲交叉研究中，对24名健康男性志愿者进行了3 mg氟哌啶醇和125 mg美多巴对持续时间辨别（DD）和反应时间的影响进行了测试。与安慰剂和美多巴相比，氟哌啶醇组DD的表现显著受损。与安慰剂相比，美多巴未显示任何变化。对于反应时间的测量获得了类似的结果。在每种药物条件下，DD的个体变化和反应时间测量之间的显着负相关性表明，药物诱导的DD损伤的受试者也显示出反应时间的增加。药物引起的DD变化和反应时间测量的几乎相同的模式可以解释为一个共同的神经基础。
The effects of 3 mg haloperidol and 125 mg Madopar on duration discrimination (DD) as well as reaction times were tested in a placebo-controlled, double-blind crossover study with 24 healthy male volunteers. Performance in DD was significantly impaired under haloperidol compared to placebo as well as to Madopar. No changes could be demonstrated for Madopar compared to placebo. Similar results were obtained for measures of reaction time. Significant negative correlations between individual changes in DD and measures of reaction time under each drug condition revealed that subjects with drug-induced impairment in DD also show an increase in reaction times. The nearly identical patterns of drug-induced changes in DD and measures of reaction time may be interpreted in terms of a common neural basis.