Inner and outer retinal volumetric and morphologic analysis of the macula with spectral domain optical coherence tomography in retinitis pigmentosa.
Inner and outer retinal volumetric and morphologic analysis of the macula with spectral domain optical coherence tomography in retinitis pigmentosa.
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DOI：
10.4103/0974-9233.95258
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发表时间：
2012-04
影响因子：
0.6
通讯作者：
Natarajan S
中科院分区：
文献类型：
--
作者：
Sheth SS;Rush RB;Natarajan S
利用光谱域光学相干断层扫描（OCT）评估色素性视网膜炎（RP）患者黄斑内外层的特征。前瞻性观察比较研究。伴有中央视力下降和中央黄斑变薄的RP组（RP组）与年龄匹配的健康对照组（对照组）一起进行光谱域OCT评估。使用E-MM5光栅方案，获得一个5 × 5 mm中央黄斑切口，黄斑内部和外部体积作为主要结果测量。RP组黄斑处视网膜内外层的结构分析也采用HD交叉线方案进行。RP组由6名RP受试者的6只眼睛组成，对照组由6名对照受试者的6只眼睛组成。RP组外黄斑体积（2.01±0.44 mm3）明显低于对照组（4.68±0.16 mm3） （P<0.05）。RP组平均黄斑内体积（2.46±0.24 mm3）与对照组（2.55±0.22 mm3）差异无统计学意义。RP组视网膜内层未见明显结构改变。RP组最佳矫正视力与外黄斑体积无显著相关（r = -0.04, P < 0.05）。光谱域OCT结果证实RP优先影响黄斑视网膜外层。虽然本研究纳入的患者数量较少，但光谱域OCT显示视网膜内层的体积和形态保存相对较好。
To use spectral domain optical coherence tomography (OCT) to assess the features of the inner and outer layers of the macula in subjects with retinitis pigmentosa (RP). Prospective observational comparative study. Subjects with RP with reduced central visual acuity and central macular thinning (RP group) underwent spectral domain OCT evaluation along with age-matched healthy control subjects (control group). Using the E-MM5 raster protocol, a 5 × 5 mm central macular cut was acquired with inner and outer macular volumes serving as the primary outcome measures. A structural analysis of the inner and outer retinal layers at the macula in the RP group was also performed using the HD cross-line protocol. The RP group comprised six eyes of six RP subjects and control group comprised six eyes of six control subjects. The outer macular volume was significantly lower (P<0.05) in the RP group (2.01±0.44 mm3) compared to the control group (4.68±0.16 mm3). There was no difference in the mean inner macular volume between the RP group (2.46±0.24 mm3) and the control group (2.55±0.22 mm3). No significant structural alteration was noted in the inner retinal layers of the RP group. There was no significant correlation (r = -0.04, P>0.05) between best-corrected visual acuity and outer macular volume in the RP group. Spectral domain OCT findings confirm that RP preferentially affects the outer retinal layers in the macula. Although the number of patients included in this study was small, it demonstrated relatively well-preserved volume and morphology of the inner retinal layers using spectral domain OCT.