Age-induced changes in the enteric nervous system in the mouse
Age-induced changes in the enteric nervous system in the mouse
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DOI：
10.1016/s0047-6374(98)00142-0
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发表时间：
1999-02-01
影响因子：
5.3
通讯作者：
Holmlund, F
中科院分区：
文献类型：
--
作者：
El-Salhy, M;Sandström, O;Holmlund, F
采用免疫细胞化学方法对1月龄、3月龄、12月龄和24月龄小鼠的肠道神经系统进行了研究。通过计算机图像分析对肌丛和粘膜下丛进行量化。在胃窦，12月龄和24月龄小鼠的肌肠和粘膜下神经节中每个神经节的神经元数量明显少于3月龄小鼠。十二指肠和结肠亦是如此。1月龄、12月龄和24月龄小鼠的中枢固有肌层神经纤维相对体积密度明显大于3月龄小鼠。在结肠中，1个月大的小鼠每毫米基线的粘膜下神经节比3个月大的小鼠少。1、12、24月龄小鼠的结肠肌肠神经节比3月龄小鼠小。在每毫米基线神经节数、神经节面积、每神经节神经元数以及肌肠丛和粘膜下丛神经纤维的相对体积密度方面，男女之间无统计学差异。由于肠道神经系统负责协调和整合肠道的运动，本文报道的与年龄相关的变化很可能与老年人胃肠运动功能障碍的增加有关。1999爱思唯尔科学爱尔兰有限公司版权所有。
The enteric nervous system of the murine gut was investigated by immunocytochemistry in 1-, 3-, 12- and 24-month-old mice, using protein gene product 9.5, a general marker for nerve elements. Myenteric and submucosal plexi were quantified by computerized image analysis. In antrum, there were significantly fewer neurones per ganglion in both myenteric and submucosal ganglia of 12- and 24-month-old mice than in 3-month-old animals. The same was true of duodenum and colon. The relative volume density of nerve fibres in antral muscularis propria was significantly greater in the 1-, 12- and 24-month-old mice than in the 3-month-old mice. In colon, there were fewer submucosal ganglia per millimetre baseline in 1-month-old mice than in 3-month-old mice. The colonic myenteric ganglion in 1-, 12- and 24-month-old mice was smaller than in 3-month-old mice. There was no statistical difference between females and males regarding the number of ganglia per millimetre baseline, ganglionic area, number of neurones per ganglion or the relative volume density of nerve fibres in either the myenteric or submucosal plexi. As the enteric nervous system is responsible for coordinating and integrating the motility of the gut, the ageing-related changes reported here may well be of some relevance for the increased gastrointestinal motility dysfunction in the elderly persons. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.