Hippocampectomized rats are capable of homing by path integration.
Hippocampectomized rats are capable of homing by path integration.
复制标题
海马切除的大鼠能够通过路径整合归巢。
DOI：
10.1037//0735-7044.113.1.19
复制
发表时间：
1999
影响因子：
1.9
通讯作者：
McNaughton,BL
中科院分区：
文献类型：
--
作者：
Alyan,S;McNaughton,BL
啮齿动物的导航至少有3种机制：引导、路径整合和标志性学习。海马体是基于远端地标的空间学习所必需的，有人认为海马体结构在更新位置细胞放电时执行一种形式的路径整合；然而，海马体对路径整合的必要性尚未明确确定。海马区广泛神经毒素损伤的大鼠和对照组大鼠接受了两项任务的训练，要求它们在完全黑暗的环境中从一个位置移动到另一个位置，然后回到起点。海马区和对照组大鼠在解决这些任务时都使用了路径整合，并且在返回路径上到达点的分布方面没有区别。我们的结论是，足以使用路径整合计算归巢向量的神经元电路位于海马体之外。
Navigation in rodents is mediated by at least 3 mechanisms: guidance, path integration, and landmark learning. The hippocampus is necessary for spatial learning based on distal landmarks, and it has been suggested that the hippocampal formation performs a form of path integration in updating place cell firing; however, the necessity of the hippocampus for path integration has not been clearly established. Rats with extensive neurotoxin lesions of the hippocampus and control rats were trained on 2 tasks in which they were required to move in total darkness from one location to another and then return to the start point. Hippocampal and control rats both used path integration in solving these tasks and did not differ in terms of the distributions of their arrival points on the return paths. We conclude that neuronal circuits sufficient for computing a homing vector using path integration are located outside the hippocampus.