Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically improved the intestinal function in a girl with short bowel syndrome -: A novel synbiotics therapy for intestinal failure
Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically improved the intestinal function in a girl with short bowel syndrome -: A novel synbiotics therapy for intestinal failure
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DOI：
10.1023/a:1010611920750
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发表时间：
2001-09-01
影响因子：
3.1
通讯作者：
Yuki, N
中科院分区：
文献类型：
--
作者：
Kanamori, Y;Hashizume, K;Yuki, N
自古以来，众所周知，发酵乳对消费者的健康有益。在过去的几十年中，这些有益作用已被证明是由于某些细菌物种的代谢作用所致，包括乳杆菌、双歧杆菌和链球菌 (1-3)。莉莉等人。 1965 年首次引入益生菌一词来形容此类细菌 (4)。益生菌被广泛用作活微生物饲料补充剂，通过改善宿主动物的肠道微生物平衡对宿主动物产生有益影响 (5)。此外，术语益生元已被用来指代一种非消化性食品成分，它选择性地针对结肠中一种或有限数量的细菌的生长和/或活性，因此具有改善宿主健康的潜力。低聚果糖、低聚半乳糖和菊粉等多种成分被用作益生元 (2, 6)。此外，益生菌和益生元的联合使用被称为合生元疗法，但有关合生元的报道很少(7, 8)。短肠综合征是指接受大肠切除术的患者出现的严重不良症状。这些患者通常营养不良，肠道扩张，导致肠道细菌过度生长综合征 (9, 10)。调节肠道细菌过度生长，特别是致病性细菌过度生长，对于短肠综合征患者改善肠道功能非常重要。为此，已使用各种抗生素来选择性地消灭肠道细菌。调节肠道细菌的另一种策略是应用益生菌和/或益生元。在本报告中，我们报告了使用合生元疗法治疗一名患有短肠综合征的 4 岁女孩。对于合生元疗法，我们使用短双歧杆菌、干酪乳杆菌和低聚半乳糖。这种新颖的联合疗法有望协同作用，改善受试者的健康。我们发现，通过这种新设计的合生元疗法，患者的肠道吸收功能和蠕动能力得到了显着改善，并且经过两年的治疗，她的进展令人满意。在病例报告之后，我们讨论了新的合生元疗法对肠衰竭的有益作用。
It has been well known since ancient times that fermented milk produces beneficial effects on the consumer’s health. In the last few decades, these beneficial effects have been demonstrated to be due to the metabolic action of some bacterial species, including lactobaccilli, bifidobacteria, and streptococci (1–3). Lilly et al. first introduced the term probiotics for such bacteria in 1965 (4). Probiotics are widely used as a live microbial feed supplement that beneficially affects the host animals by improving their intestinal microbial balance (5). Additionally the term prebiotics has been adopted to refer to a nondigestive food ingredient that selectively targets the growth and/or activity of one or a limited number of bacteria in the colon and, thus, has the potential to improve host health. Several types of ingredients, such as fructooligosaccharides, galactooligosaccharides, and inulin, are used as prebiotics (2, 6). Furthermore, the combined use of probiotics and prebiotics is called synbiotics therapy, but few reports concerning synbiotics have been published (7, 8). Short bowel syndrome refers to seriously adverse symptoms that are seen in patients who have been subjected to a massive bowel resection. These patients are usually malnourished and have a dilated intestine that results in intestinal bacterial overgrowth syndrome (9, 10). Regulation of intestinal bacterial overgrowth, especially pathogenic bacterial overgrowth, is very important in patients with short bowel syndrome to attain any improvement in intestinal function. For this purpose, various antibiotics have been used to eliminate the intestinal bacteria selectively. An alternative strategy for regulating intestinal bacteria is to apply probiotics and/or prebiotics. In this report, we report the use of synbiotics therapy in the treatment of a 4-year-old girl suffering from short bowel syndrome. For the synbiotics therapy, we used Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides. This novel combination therapy was expected to act synergistically for the improvement of the subject’s health. We found that the patient’s intestinal absorptive function and motility were dramatically improved by this newly designed synbiotics therapy, and she progressed satisfactorily after 2 years of the therapy. Following the case report, we discuss the beneficial effects of the new synbiotics therapy for intestinal failure.