microRNA-132 as a negative regulator in NF-κB signaling pathway via targeting IL-1β in miiuy croaker
microRNA-132 as a negative regulator in NF-κB signaling pathway via targeting IL-1β in miiuy croaker
复制标题
microRNA-132 通过靶向 miiuy 黄花鱼中的 IL-1 beta 作为 NF-kappa B 信号通路的负调节因子
DOI：
10.1016/j.dci.2021.104113
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发表时间：
2021-05-19
影响因子：
2.9
通讯作者：
Xu, Tianjun
中科院分区：
文献类型：
--
作者：
Dong, Wenjing;Gao, Wenya;Xu, Tianjun
先天免疫系统是抵御病原体入侵的第一道防线。它可以对入侵的病原微生物做出快速的免疫反应，从而消除入侵的病原体，保护身体免受伤害。MicroRNAs是一类非编码的小分子核糖核酸，是重要的多功能免疫调节因子。在这项研究中，我们研究了miR-132作为IL-1β介导的炎症的关键调节因子的作用。MiR-132的种子区通过与IF-1β的3‘端非编码区结合来调节基因表达，并在转录后水平抑制IL-1β的表达。更重要的是，miR-132通过靶向IF-1β抑制内毒素诱导的NF-kappaB信号通路，从而防止过度的炎症反应导致自身免疫性疾病。这些结果将有助于更好地理解硬骨鱼复杂的调控机制。
The innate immune system is the first line of defense against the invasion of pathogens. It can make a rapid immune response to the invading pathogenic microorganisms, thereby eliminating the invading pathogens and protecting the body from harm. microRNAs are a family of small non-coding ribonucleic acid molecules, which are important and multifunctional regulator of immune response. In this study, we studied the role of miR-132 as a key regulatory factor of IL-1 beta-mediated inflammation. The seed region of miR-132 can regulate gene expression by binding to the 3'UTR of if -1 beta, and inhibit the expression of IL-1 beta at the post-transcriptional level. More importantly, miR-132 inhibits LPS-induced NF-kappa B signaling pathway by targeting if -1 beta, thereby preventing excessive inflammatory response from causing autoimmune diseases. These results will help to better understand the complex regulatory mechanisms of teleost fishes.