Diversity of structures and functions of oxo-bridged non-heme diiron proteins.
Diversity of structures and functions of oxo-bridged non-heme diiron proteins.
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DOI：
10.1016/j.abb.2021.108917
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发表时间：
2021-07-15
影响因子：
3.9
通讯作者：
Davidson VL
中科院分区：
文献类型：
--
作者：
Caldas Nogueira ML;Pastore AJ;Davidson VL
氧桥二铁蛋白是一类独特的非血红素铁蛋白。它们的活性位点由两个由氨基酸侧链配位的铁和一个与每个铁相互作用的桥氧组成。这些蛋白质是铁蛋白超家族的成员，并且共享提供协调铁的残基的四α-螺旋束的结构特征。不同的蛋白质也显示出广泛的结构和功能。这个家族的一个原型是血红蛋白，它的功能是氧转运蛋白。其他几种hemerythrin样蛋白已被描述为具有多种功能，包括氧和铁传感以及催化活性。红赤霉素与过氧化氢反应，红赤霉素样蛋白除了氧桥二铁中心外，还具有红赤霉素结构域。具有氧桥铁的其他氧化还原酶包括充当O2或NO还原酶、核糖核苷酸还原酶和甲烷单加氧酶的黄二铁蛋白。铁蛋白在铁氧化酶中心有一个氧桥二铁，在这些蛋白的铁储存功能中起作用。也有细菌铁蛋白表现出催化活性。这一广泛的氧桥双铁蛋白的结构和功能的描述和比较在这篇评论。
Oxo-bridged diiron proteins are a distinct class of non-heme iron proteins. Their active sites are composed of two irons that are coordinated by amino acid side chains, and a bridging oxygen that interacts with each iron. These proteins are members of the ferritin superfamily and share the structural feature of a four α-helix bundle that provides the residues that coordinate the irons. The different proteins also display a wide range of structures and functions. A prototype of this family is hemerythrin, which functions as an oxygen transporter. Several other hemerythrin-like proteins have been described with a diversity of functions including oxygen and iron sensing, and catalytic activities. Rubrerythrins react with hydrogen peroxide and rubrerythrin-like proteins possess a rubredoxin domain, in addition to the oxo-bridged diiron center. Other redox enzymes with oxo-bridged irons include flavodiiron proteins that act as O2 or NO reductases, ribonucleotide reductase and methane monooxygenase. Ferritins have an oxo-bridged diiron in the ferroxidase center of the protein, which plays a role in the iron storage function of these proteins. There are also bacterial ferritins that exhibit catalytic activities. The structures and functions of this broad class of oxo-bridged diiron proteins are described and compared in this review.
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影响因子：
2.9
作者：
Bou-Abdallah, F.;Yang, H.;Awomolo, A.;Cooper, B.;Woodhall, M. R.;Andrews, S. C.;Chasteen, N. D.
通讯作者：
Chasteen, N. D.
影响因子：
15
作者：
Arnold AR;Zhou A;Barton JK
通讯作者：
Barton JK
DOI：
10.1016/j.bbagen.2015.02.010
发表时间：
2015-06-01
影响因子：
3
作者：
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通讯作者：
Arias, Diego G.
影响因子：
3.7
作者：
Alvarez-Carreño C;Becerra A;Lazcano A
通讯作者：
Lazcano A
影响因子：
14.8
作者：
Ebrahimi, Kourosh Honarmand;Bill, Eckhard;Hagen, Wilfred R.
通讯作者：
Hagen, Wilfred R.