Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism
Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism
复制标题
胆固醇转运中的脂蛋白：其结构基础和功能机制的亮点和最新见解
DOI：
10.1088/1674-1056/27/2/028702
复制
发表时间：
2018
影响因子：
1.7
通讯作者：
Zhang Lei
中科院分区：
文献类型：
--
作者：
Chen Shu-Yu;Li Na;Jin Tao-Li;Gou Lu;Hao Dong-Xiao;Tian Zhi-Qi;Zhang Sheng-Li;Zhang Lei
Lipoproteins are protein-lipid macromolecular assemblies which are used to transport lipids in circulation and are key targets in cardiovascular disease (CVD). The highly dynamic lipoprotein molecules are capable of adopting an array of conformations that is crucial to lipid transport along the cholesterol transport pathway, among which high-density lipoprotein (HDL) and low-density lipoprotein (LDL) are major players in plasma cholesterol metabolism. For a more detailed illustration of cholesterol transport process, as well as the development of therapies to prevent CVD, here we review the functional mechanism and structural basis of lipoproteins in cholesterol transport, as well as their structural dynamics in the plasma lipoprotein (HDL and LDL) elevations, in order to obtain better quantitative understandings on structure–function relationship of lipoproteins. Finally, we also provide an approach for further research on the lipoprotein in cholesterol transport.
