Synthesis of Zinc-Containing Amorphous Calcium Phosphate
Synthesis of Zinc-Containing Amorphous Calcium Phosphate
复制标题
含锌无定形磷酸钙的合成
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
K. Toda
中科院分区：
文献类型：
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作者：
Tomohiro Uchino;K. Toda
锌是人体必需的微量元素，对骨形成有重要作用。骨质疏松症是由于破骨细胞和成骨细胞活性失衡而发生的。破骨细胞活性降低了周围身体环境的pH值。治疗药物释放材料响应破骨细胞的活动，预计将是一个控制释放的材料。采用湿法合成法制备了含锌无定形磷酸钙粉体。所得粉末的Zn含量高于初始含量。ACP粉体在湿法合成时易带锌。在磷酸盐缓冲盐水中浸泡24小时后，所有合成粉末均转化为低结晶磷灰石。另一方面，在乙酸缓冲液中浸泡24小时后，所有这些粉末溶解。含锌ACP粉末有望成为一种锌的控释材料。
Zinc is an essential trace element in body and has an important role of bone formation. Osteoporosis occurs by imbalance of osteoclasts and osteoblasts activity. The osteoclasts activity lowers the pH of peripheral body environment. Therapeutic agents release material in response to the osteoclasts activity is expected to be a controlled released material. In this study, Zn-containing amorphous calcium phosphate (ACP) powder was synthesized by wet synthesis. Zn content of obtained powders was higher than that of beginning content. ACP powders could be easy to take Zn at wet synthesis. After soaking in phosphate buffered saline for 24 hours, all of synthetic powders were transformed into low crystalline apatite. On the other hand, after soaking in acetic acid buffer for 24 hours, all these powders dissolved. Zn-containing ACP powders are expected to be a Zn controlled released material.
影响因子：
14
作者：
Takagi, S;Chow, LC;Ishikawa, K
通讯作者：
Ishikawa, K