IDENTIFICATION OF TAENIA-SOLIUM ANTIGENS IN CEREBROSPINAL-FLUID AND LARVAL ANTIGENS FROM PATIENTS WITH NEUROCYSTICERCOSIS
IDENTIFICATION OF TAENIA-SOLIUM ANTIGENS IN CEREBROSPINAL-FLUID AND LARVAL ANTIGENS FROM PATIENTS WITH NEUROCYSTICERCOSIS
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DOI：
10.4269/ajtmh.1989.41.50
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发表时间：
1989-07-01
影响因子：
3.3
通讯作者：
KUHN, RE
中科院分区：
文献类型：
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作者：
ESTRADA, JJ;ESTRADA, JA;KUHN, RE
在18例疑似脑囊虫病患者的脑脊液（CSF）中，有14例检测到190和230 kDa的猪带绦虫幼虫抗原。其中9例经组织病理学证实。在T.从6名受感染患者的大脑中取出的绦虫幼虫。其中两种抗原与T.在脑脊液中检测到了抗原聚丙烯酰胺凝胶电泳和电免疫印迹分析用于鉴定和表征。兔抗幼虫抗血清中的抗体和感染个体血清中的抗体识别幼虫囊液和感染患者CSF中的幼虫抗原。
Two antigens (190 and 230 kDa) of the larvae of Taenia solium were detected inthe cerebrospinal fluid (CSF) of 14 of 18 patients in which neurocysticercosis was suspected. Nine of these were confirmed by histopathology. Seven antigens were detected in cyst fluid of T. solium larvae removed from the brains of 6 infected patients. Two of these antigens had the same Mr as the T. solium antigens detected in the CSF. Polyacrylamide gel electrophoresis and electro-immunoblotting analyses were used for the identification and characterization. Antibodies in rabbit anti-larval antiserum and antibodies in sera of infected individuals recognized the same larval antigens in the larval cyst fluids and in the CSF of infected patients.