Patterns of prolactin secretion in the syndrome of general resistance to thyroid hormones.
Patterns of prolactin secretion in the syndrome of general resistance to thyroid hormones.
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甲状腺激素一般抵抗综合征中催乳素分泌的模式。
DOI：
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发表时间：
1984
影响因子：
5.8
通讯作者：
B. Shapiro
中科院分区：
文献类型：
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作者：
J. Sisson;N. Hopwood;S. Sauder;B. Shapiro
本文对三例甲状腺激素不完全抵抗患者的促甲状腺激素（TSH）和催乳素（PRL）分泌动态进行了研究。第一名患者的结果与其他两名患者的结果不同。第一个病人曾接受过放射性碘治疗，但临床甲状腺功能正常时，随后与超生理量的T3和T4治疗。增加剂量的T4从0.2-0.3毫克/天引起血清TSH水平下降和TSH的增量较小，注射TRH在这个病人。另外两名患者未接受治疗，但基础TSH水平和TSH对TRH的反应与第一名患者相似。然而，第一名患者对注射甲氧氯普胺的TSH反应明显高于其他两名患者。在第一个病人的PRL的基础水平升高，在两个T4剂量，而且，她的PRL反应TRH和甲氧氯普胺被夸大，与正常值相比，不成比例的促甲状腺激素对这些刺激剂的反应。相反，另外两名患者的基础PRL浓度正常，对TRH和甲氧氯普胺的PRL反应正常或接近正常。我们的结论是，在甲状腺激素抵抗综合征，有异质性模式的PRL分泌。甲状腺激素细胞和催乳激素细胞的多巴胺能张力在综合征患者中也不同。
The dynamics of TSH and PRL secretion were studied in three patients with incomplete generalized resistance to thyroid hormones. Results in the first patient differed from those in the other two. The first patient had been treated previously with radioiodine but was clinically euthyroid when subsequently treated with supraphysiological quantities of T3 and T4. Increasing doses of T4 from 0.2-0.3 mg/day caused a decline in serum TSH levels and lesser increments in TSH to injected TRH in this patient. The other two patients had not been treated, but had basal TSH levels and TSH responses to TRH similar to those in the first patient. However, the TSH response to injected metoclopramide in the first patient was substantially higher than the responses in the other two patients. The basal levels of PRL in the first patient were elevated at both T4 doses; also, her PRL responses to TRH and metoclopramide were exaggerated and, compared to normal values, disproportionate to her TSH responses to these provocative agents. In contrast, the other two patients had normal basal PRL concentrations and normal or near-normal PRL responses to TRH and metoclopramide. We conclude that within the syndrome of resistance to thyroid hormones, there are heterogeneous patterns of PRL secretion. Dopaminergic tone on thyrotrophs and lactotrophs also differs among patients with the syndrome.
催乳素增强多巴胺和去甲肾上腺素从灌注的内侧基底下丘脑片段中的释放。
影响因子：
4.8
作者：
Foreman,MM;Porter,JC
通讯作者：
Porter,JC