The Immediate Pulmonary Disease Pattern following Exposure to High Concentrations of Chlorine Gas
The Immediate Pulmonary Disease Pattern following Exposure to High Concentrations of Chlorine Gas
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DOI：
10.1155/2013/325869
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发表时间：
2013-01-01
影响因子：
4.3
通讯作者：
Svendsen, Erik R.
中科院分区：
文献类型：
--
作者：
Balte, Pallavi P.;Clark, Kathleen A.;Svendsen, Erik R.
背景。根据 2005 年 ATS/ERS 指南和 Mannino 等人修改的 GOLD 标准，将肺部疾病分为阻塞性、限制性和混合型。 (2003)，但这些指南对于涉及大规模伤亡的情况下的简单肺活量测定的用途有限。目的。本研究的目的是将这些指南应用于南卡罗来纳州格兰尼特维尔火车脱轨后吸入高浓度氯气后接受简单肺活量测定的患者。方法。我们回顾性研究了 10 名患者的肺功能。为了对肺部疾病模式进行分类，我们使用了 2005 年 ATS/ERS 指南和修改后的 GOLD 标准以及我们自己使用可用的简单肺活量测定数据制定的标准。结果。我们在修改后的 GOLD 和我们的标准的患者中发现了主要的限制性模式，这与其他氯暴露研究相反，其中阻塞性模式更常见。与修改后的 GOLD 和我们的标准相比，2005 年 ATS/ERS 指南低估了限制性疾病的频率。结论。吸入刺激性气体后肺部疾病模式的诊断非常重要。需要制定可接受的标准，通过简单的肺活量测定来评估导致大规模伤亡和医院患者激增的事件中的肺部疾病。
Background. Classification of pulmonary disease into obstructive, restrictive, and mixed patterns is based on 2005 ATS/ERS guidelines and modified GOLD criteria by Mannino et al. (2003), but these guidelines are of limited use for simple spirometry in situations involving mass casualties. Aim. The purpose of this study was to apply these guidelines to patients who underwent simple spirometry following high concentration of chlorine gas inhalation after a train derailment in Graniteville, South Carolina. Methods. We retrospectively investigated lung functions in ten patients. In order to classify pulmonary disease pattern, we used 2005 ATS/ERS guidelines and modified GOLD criteria along with our own criteria developed using available simple spirometry data. Results. We found predominant restrictive pattern in our patients with both modified GOLD and our criteria, which is in contrast to other chlorine exposure studies where obstructive pattern was more common. When compared to modified GOLD and our criteria, 2005 ATS/ERS guidelines underestimated the frequency of restrictive disease. Conclusion. Diagnosis of pulmonary disease patterns is of importance after irritant gas inhalation. Acceptable criteria need to be developed to evaluate pulmonary disease through simple spirometry in events leading to mass casualty and patient surge in hospitals.