Cognition and mortality from the major causes of death: the Health and Lifestyle Survey
Cognition and mortality from the major causes of death: the Health and Lifestyle Survey
复制标题
DOI：
10.1016/j.jpsychores.2008.02.017
复制
发表时间：
2008-08-01
影响因子：
4.7
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Shipley, Beverly A.;Der, Geoff;Deary, Ian J.
目的：调查反应时间和认知对死因特异性死亡风险的影响，并检查在调整现有的社会经济、生活方式和健康因素后，是否仍存在任何相关性。方法：参与者来自英国健康和生活方式调查。样本包括6424名社区居民，年龄在18至97岁之间的基线（1984/1985）。收集社会人口统计学，生活方式，健康和生理信息以及认知测试，包括简单（SRT）和选择（CRT）反应时间，短期记忆测试和视觉空间推理测试。参与者被跟踪了21年的原因特异性死亡率。结果如下：在控制了年龄和性别后，反应时间更慢、变化更大以及认知能力更差与心血管疾病、中风和呼吸系统疾病的死亡风险更高相关。调整所有协变量后，观察到轻微衰减。然而，只有CRT平均值与呼吸系统疾病死亡显著相关。没有发现与冠心病、肺癌和所有非肺癌相关。在60岁以上的人群中，大多数人获得了显着的认知死亡率相关性。通过在忽略认知测试5年内死亡的个体后重新分析数据，部分排除了反向因果关系的可能性。结论：反应时间更慢、变化更大、认知能力更差与心血管疾病、中风和呼吸系统疾病的死亡风险增加有关。反向因果关系的可能性需要进一步检验。(C)2008年爱思唯尔公司All rights reserved.
Objective: To investigate the influence of reaction time and cognition on the risk of death from cause-specific mortality and to examine whether any association found remains after adjustment for available socioeconomic, lifestyle, and health factors. Methods: Participants were from the UK Health and Lifestyle Survey. The sample consisted of 6424 community dwelling individuals aged between 18 and 97 years at baseline (1984/1985). Sociodemographic, lifestyle, health, and physiological information was collected alongside cognitive testing which included simple (SRT) and choice (CRT) reaction time, a short-term memory test, and a test of visual-spatial reasoning. Participants have been followed for 21 years for cause-specific mortality. Results: Slower and more variable reaction times and poorer cognitive performance were associated with a higher risk of death from cardiovascular disease, stroke, and respiratory disease after controlling for age and sex. Slight attenuation was noted after adjustments for all covariates. However, only CRT mean remained significantly associated with death from respiratory disease. No associations were found for coronary heart disease, lung cancer, and all nonlung cancers. Significant cognition-mortality associations were mostly obtained in those aged over 60 years. The possibility of reverse causality was partly excluded by reanalysing the data after omitting individuals who died within 5 years of cognitive testing. Conclusions: Slower and more variable reaction times and poorer cognitive performance were related to an increased risk of mortality from cardiovascular disease, stroke, and respiratory disease. The possibility of reverse causality requires further testing. (C) 2008 Elsevier Inc. All rights reserved.