A feasibility study for electrical impedance tomography as a means to monitor tissue electroporation for molecular medicine
A feasibility study for electrical impedance tomography as a means to monitor tissue electroporation for molecular medicine
复制标题
DOI：
10.1109/10.991168
复制
发表时间：
2002-04-01
影响因子：
4.6
通讯作者：
Otten, DM
中科院分区：
文献类型：
--
作者：
Davalos, RV;Rubinsky, B;Otten, DM
分子医学涉及将大分子（如药物或基因构建体）引入身体的特定细胞。使用电脉冲渗透细胞膜的电穿孔是实现这一点的方法。然而，与其他分子医学程序一样，它缺乏实时机制来检测和控制哪些细胞受到影响。我们提出并证明，通过计算机模拟，电阻抗断层扫描具有潜在的检测和成像组织中的细胞电穿孔的实时，从而提供反馈控制电穿孔。
Molecular medicine involves the introduction of macromolecules, such as drugs or gene constructs, into specific cells of the body. Electroporation, which uses electric pulses to permeate cell membranes, is a method for achieving this. However, as with other molecular medicine procedures, it lacks a real-time mechanism to detect and control which cells have been affected. We propose and demonstrate, via computer simulation, that electrical impedance tomography has the potential for detecting and imaging electroporation of cells in tissue in real-time, thereby providing feedback for controlling electroporation.