Midlife Use of Written Japanese and Protection From Late Life Dementia
Midlife Use of Written Japanese and Protection From Late Life Dementia
复制标题
DOI：
10.1097/ede.0b013e3181b09332
复制
发表时间：
2009-09-01
期刊：
影响因子：
5.4
通讯作者：
White, Lon
中科院分区：
文献类型：
--
作者：
Crane, Paul K.;Gibbons, Laura E.;White, Lon
工作背景：认知储备假说预测，使用书面日语应该可以预防痴呆症，因为与书面英语相比，日语的表意文字比较复杂。我们试图检验这一假设的分析从纵向研究的日裔美国人manes.Methods：参与者是第二代日裔美国人的男性（Nisei）的岛屿上的Oakland，夏威夷，谁被认为是在1965年，并在随后的检查，以检测痴呆症开始于1991年至1993年。1965年自我报告了日语口语和书面语的使用（分析1和2），1994-1996年自我报告了中年日语书面语和英语书面语的使用（分析3）。我们使用逻辑回归分析了1991-1993年的痴呆流行结局（分析1，n = 3139），使用考克斯比例风险回归分析了1994-2002年（分析2，n = 2299）和1997-2002年（分析3，n = 1655）的痴呆事件结局。痴呆结局包括全因痴呆、可能和可能的阿尔茨海默病和可能的血管性痴呆。我们调整模型的可能性和可能的confers.Results：参与者谁报告熟练的书面日语年龄较大，收入较低。对于分析1，有154例痴呆，74例阿尔茨海默病和43例血管性痴呆;对于分析2，236例痴呆，138例阿尔茨海默病和45例血管性痴呆;对于分析3，125例痴呆，80例阿尔茨海默病和20例血管性痴呆。自我报告的熟练程度与书面日语和任何痴呆outcome.Conclusions：熟练的书面日语之间的调整模型没有关系似乎是保护痴呆症。
Background: The cognitive reserve hypothesis would predict that use of written Japanese should confer protection against dementia because of the complexity of its ideograms compared with written English. We sought to test this hypothesis in analyses from a longitudinal study of Japanese-American men.Methods: Participants were second-generation Japanese-American men (Nisei) on the island of Oahu, Hawaii, who were seen in 1965 and in subsequent examinations to detect dementia beginning in 1991-1993. Use of spoken and written Japanese was self-reported in 1965 (Analyses 1 and 2), and midlife use of written Japanese and written English was self-reported in 1994-1996 (Analysis 3). We analyzed prevalent dementia outcomes in 1991-1993 (Analysis 1, n = 3 139) using logistic regression, and incident dementia outcomes in 1994-2002 (Analysis 2, n = 2299) and in 1997-2002 (Analysis 3, n = 1655) using Cox proportional hazards regression. Dementia outcomes included all-cause dementia, probable and possible Alzheimer disease, and probable vascular dementia. We adjusted models for probable and possible confounders.Results: Participants who reported proficiency with written Japanese were older and had lower incomes. For Analysis 1, there were 154 prevalent cases of dementia, 74 of Alzheimer disease, and 43 of vascular dementia; for Analysis 2, 236 incident cases of dementia, 138 of Alzheimer disease, and 45 of vascular dementia; and for Analysis 3, 125 incident cases of dementia, 80 of Alzheimer disease, and 20 of vascular dementia. There was no relationship in adjusted models between self-reported proficiency with written Japanese and any dementia outcomes.Conclusions: Proficiency with written Japanese does not appear to be protective for dementia.