BAG3-mediated proteostasis at a glance
BAG3-mediated proteostasis at a glance
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DOI：
10.1242/jcs.203679
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发表时间：
2017-09-01
影响因子：
4
通讯作者：
Hoehfeld, Joerg
中科院分区：
文献类型：
--
作者：
Klimek, Christina;Kathage, Barbara;Hoehfeld, Joerg
细胞和生物体的生存取决于维持蛋白质组的能力，即使在威胁蛋白质完整性的条件下。BCL 2相关的产氧基因3（BAG3）对于应激细胞中的蛋白质稳态（proteostasis）是必不可少的。由于其多结构域结构，它参与了对蛋白质组维护至关重要的各种过程。BAG3促进分子伴侣的活性，隔离和浓缩错误折叠的蛋白质，启动自噬处置，并平衡转录，翻译和降解。在这篇Cell Science at a Glance文章和随附的海报中，我们讨论了这种多功能蛋白质稳定工具的功能，重点是机械应力保护，并描述了BAG3对人体生理学和病理生理学的重要性。
Cellular and organismal survival depend on the ability to maintain the proteome, even under conditions that threaten protein integrity. BCL2-associated athanogene 3 (BAG3) is essential for protein homeostasis (proteostasis) in stressed cells. Owing to its multidomain structure, it engages in diverse processes that are crucial for proteome maintenance. BAG3 promotes the activity of molecular chaperones, sequesters and concentrates misfolded proteins, initiates autophagic disposal, and balances transcription, translation and degradation. In this Cell Science at a Glance article and the accompanying poster, we discuss the functions of this multi-functional proteostasis tool with a focus on mechanical stress protection and describe the importance of BAG3 for human physiology and pathophysiology.