Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder
Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder
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DOI：
10.1111/j.1399-5618.2011.00952.x
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发表时间：
2011-08-01
影响因子：
5.4
通讯作者：
Osby, Urban
中科院分区：
文献类型：
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作者：
Backlund, Lena;Nikamo, Pernilla;Osby, Urban
目的：有几个基因位点被认为与双相情感障碍有关，但结果一直不一致。研究双相症状和候选基因之间的关联可能会更好地揭示这种关系。在这里，我们探讨双相情感障碍的关键症状和P2 RX 7基因之间的关联。方法：躁狂症的关键症状进行了评估，在两组药物治疗的双相情感障碍患者（n = 171和n = 475）在两个专门的门诊情感障碍和三个定期精神科门诊部在瑞典。所有躁狂症状之间的关系，根据DSM-IV输入主成分分析。我们使用病例-病例模型来减少遗传异质性，并测试与躁狂症状相关的四个因素之间的关联及其与P2 RX 7基因中四个单核苷酸多态性之间的关联。认知症状、注意力不集中、多话和思维障碍的组合与第1组中P2 RX 7基因中的rs 1718119显著相关[比值比（OR）= 1.78; p = 0.011]。在第二组中重新检验了相关性（OR = 1.42; p = 0.009）。在总样本中，这种关联甚至更强（OR = 1.49; p < 0.001）。其他因素均与P2 RX 7基因无关。在第一个因素中，注意力分散症状占了与rs 1718119相关的显著部分（p = 0.016）。结论：双相情感障碍的特定症状与P2 RX 7基因之间存在关联。这一发现可能为阐明双相情感障碍症状背后的神经生物学开辟了新的途径。
Objective: Several genetic loci have been suggested to be associated with bipolar disorder but results have been inconsistent. Studying associations between bipolar symptoms and candidate genes may better expose this relationship. Here we investigate the association between bipolar key symptoms and the P2RX7 gene.Methods: Key symptoms of mania were rated in two sets of medicated bipolar disorder patients (n = 171 and n = 475) at two specialized outpatient clinics for affective disorders and three regular psychiatric outpatient units in Sweden. The relationships between all manic symptoms according to DSM-IV were entered in a principal component analysis. We used a case-case model to reduce the genetic heterogeneity and tested associations between four factors related to manic symptoms and their association to four single nucleotide polymorphisms in the P2RX7 gene.Results: The combination of the cognitive symptoms, distractibility, talkativeness, and thought disorder was significantly associated with rs1718119 in the P2RX7 gene in Set 1 [odds ratio (OR) = 1.78; p = 0.011]. The association was re-tested in the second set (OR = 1.42; p = 0.009). In the total sample, the association was even stronger (OR = 1.49; p < 0.001). None of the other factors was associated with the P2RX7 gene. Within the first factor, the distractibility symptom accounted for a significant portion of the association to rs1718119 (p = 0.016).Conclusion: There is an association between specific symptoms of bipolar disorder and the P2RX7 gene. This finding may open up new approaches to elucidating the neurobiology behind bipolar symptoms.