Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol
Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol
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DOI：
10.1017/s1461145709990617
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发表时间：
2010-05-01
影响因子：
4.8
通讯作者：
McGuire, Philip
中科院分区：
文献类型：
--
作者：
Fusar-Poli, Paolo;Allen, Paul;McGuire, Philip
大麻是使用最广泛的非法药物，对动物和人类的焦虑程度有深远的影响。虽然最近的研究有助于更好地理解这些影响的神经功能相关性，表明杏仁核和扣带皮层的参与，但它们的相互影响仍然是未知的。在这项研究中，动态因果模型（DCM）和贝叶斯模型选择（BMS）被用来探讨纯化合物的C。Sativa [600 mg大麻二酚（CBD）和10 mg Delta（9）-四氢大麻酚（Delta（9）-THC）]对15名健康受试者的前额叶-皮层下有效连接的影响，这些受试者在观看引起不同程度焦虑的面孔时进行了双盲随机，安慰剂对照的fMRI范例。在安慰剂条件下，BMS确定了一个模型，其中驱动输入通过前扣带回进入，杏仁核和前扣带回之间的前向内在连接是最佳拟合。CBD而不是Delta（9）-THC在对恐惧面孔的神经反应中破坏了这些区域之间的前向连接。这是第一项研究表明，CBD对前额叶-亚临界连接的破坏可能代表其抗焦虑特性的神经生理学相关性。
Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta(9)-tetrahydrocannabinol (Delta(9)-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta(9)-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocrtical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.