Use of Serum Homocysteine to Predict Stroke, Coronary Heart Disease and Death in Ethnic Chinese-12-Year Prospective Cohort Study -
Use of Serum Homocysteine to Predict Stroke, Coronary Heart Disease and Death in Ethnic Chinese-12-Year Prospective Cohort Study -
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DOI：
10.1253/circj.cj-08-1077
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发表时间：
2009-08-01
影响因子：
3.3
通讯作者：
Lee, Yuan-Teh
中科院分区：
文献类型：
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作者：
Sun, Yu;Chien, Kuo-Liong;Lee, Yuan-Teh
背景：关于亚洲血清总同型半胱氨酸 (Hcy) 与血管疾病之间关系的前瞻性数据有限，因为很少有研究评估 Hey 预测血管疾病和死亡风险的切点。方法和结果：一项基于社区的前瞻性队列研究，对 2,009 名参与者进行了随访，这些参与者在 1994 年基线时没有中风、冠心病 (CHD) 和癌症，对 Lip 进行了随访至 2007 年（中位数 11.95）年）；有 114 例中风病例、95 例冠心病病例和 380 例死亡病例记录在案。 Cox 比例风险模型用于检验 Hey 与中风、冠心病和全因死亡发生率之间的关联。绘制受试者工作特征曲线以确定 Hcy 在风险预测中的切点。在完全调整的模型中，Hey 水平仍然与心血管事件和死亡显着相关。 Hey > 9.47、mu mol/L（敏感性 81.1%，特异性 54.3%）的参与者心血管事件风险增加 2.3 倍（95% 置信区间 (CI)，1.24-4.18，P=0.008），Hey > 11.84、mu mol/L（敏感性 49.7%，特异性 84.0%）的参与者心血管事件风险增加 2.3 倍。 2.4 倍死亡风险（95%CI，1.76-3.32，P
Background: Prospective data about the association between serum total homocysteine (Hcy) and vascular disease in Asia is limited because few investigations have evaluated the cutpoint of Hey for predicting the risk of vascular disease and death.Methods and Results: A community-based prospective cohort stud), of 2,009 participants, who were free from stroke, coronary heart disease (CHD) and cancer at baseline in 1994 were followed Lip to 2007 (median 11.95 years); there were 114 documented cases of stroke, 95 of CHD and 380 deaths. Cox proportional hazard model was used to examine the association between Hey and the incidence of stroke, CHD, and all-cause death. The receiver-operating characteristic Curve was performed for determining the cutpoint of Hcy in risk prediction. Hey levels remained significantly associated with cardiovascular events and death in fully adjusted models. Participants with Hey >9.47, mu mol/L (sensitivity 81.1%, specificity 54.3%) had a 2.3-fold risk for cardiovascular events (95% confidence interval (CI), 1.24-4.18, P=0.008), and participants with Hey >11.84, mu mol/L (sensitivity 49.7%, specificity 84.0%) had a 2.4-fold risk for death (95%CI, 1.76-3.32, P