Cilia-based flow network in the brain ventricles
Cilia-based flow network in the brain ventricles
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DOI：
10.1126/science.aae0450
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发表时间：
2016-07-08
期刊：
影响因子：
56.9
通讯作者：
Eichele, Gregor
中科院分区：
文献类型：
--
作者：
Faubel, Regina;Westendorf, Christian;Eichele, Gregor
脑脊液通过脑室腔传递许多生理上重要的信号因子。我们研究了小鼠大脑第三脑室中脑脊液的运输，发现了纤毛模块的高度组织化模式，这些模块共同产生了一个流体流动网络，允许在该脑室内进行精确运输。我们还发现了一个基于纤毛的开关，它可靠地和周期性地改变流动模式，以创建一个动态的细分，可以控制物质在第三脑室的分布。在大鼠和猪的第三脑室中也存在复杂的血流模式。我们的工作表明，纤毛上皮细胞可以产生和维持复杂的，时空调节的流动网络。
Cerebrospinal fluid conveys many physiologically important signaling factors through the ventricular cavities of the brain. We investigated the transport of cerebrospinal fluid in the third ventricle of the mouse brain and discovered a highly organized pattern of cilia modules, which collectively give rise to a network of fluid flows that allows for precise transport within this ventricle. We also discovered a cilia-based switch that reliably and periodically alters the flow pattern so as to create a dynamic subdivision that may control substance distribution in the third ventricle. Complex flow patterns were also present in the third ventricles of rats and pigs. Our work suggests that ciliated epithelia can generate and maintain complex, spatiotemporally regulated flow networks.