Induction of liver tumor in Sherman strain female rats by polychlorinated biphenyl aroclor 1260.
Induction of liver tumor in Sherman strain female rats by polychlorinated biphenyl aroclor 1260.
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多氯联苯aroclor 1260诱导Sherman品系雌性大鼠肝肿瘤。
DOI：
10.1093/jnci/55.6.1453
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
V. Burse
中科院分区：
文献类型：
--
作者：
R. Kimbrough;R. Squire;R. Linder;J. Strandberg;R. Montali;V. Burse
用100 ppm多氯联苯（Aroclor 1260）灌养Sherman品系雌性大鼠200只，饲喂约21个月。这些老鼠在23个月大时被杀死。184只实验动物中的26只和173只对照动物中的1只患有肝细胞癌。除了184只实验大鼠中的146只外，没有一只对照组的肝脏出现肿瘤结节，173只对照组中的28只和184只实验动物中的182只肝脏出现肝细胞改变。因此，在这些大鼠的饮食中添加多氯联苯Aroclor 1260，会产生肝癌的作用。其他器官肿瘤的发生率在实验组和对照组之间没有明显差异。
Sherman strain female rats (200) were fed 100 ppm of polychlorinated biphenyl (Aroclor 1260) for apporximately 21 months, and 200 female rats were kept as controls. The rats were killed when 23 months old. Twenty-six of 184 experimental animals and 1 of 173 controls had hepatocellular carcinomas. None of the controls but 146 of 184 experimental rats had neoplastic nodules in their livers, and areas of hepatocellular alteration were noted in 28 of 173 controls and 182 of 184 experimental animals. Thus the polychlorinated biphenyl Aroclor 1260, when fed in the diet, had a hepatocarcinogenic effect in these rats. The incidence of tumors in other organs did not differ appreciably between the experimental and control groups.