The parasexual lifestyle of Candida albicans.
The parasexual lifestyle of Candida albicans.
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DOI：
10.1016/j.mib.2015.06.017
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发表时间：
2015-12
影响因子：
5.4
通讯作者：
Bennett RJ
中科院分区：
文献类型：
--
作者：
Bennett RJ
白色念珠菌是一种常见的人类共生菌，也是最常见的人类真菌病原体。这种生活方式取决于真菌经历快速遗传和表观遗传变化的能力，通常是对特定环境线索的反应。白色念珠菌的准有性循环已被定义，与相关的模型酵母（酿酒酵母）相比，它包括几个独特的特性。新颖的特征包括通过表型转换严格调控交配、有性生物膜内增强的接合，以及代替传统减数分裂的协调染色体丢失程序。预计这些适应性中的一些与白色念珠菌定植哺乳动物宿主的能力共同进化。
Candida albicans is both a prevalent human commensal and the most commonly encountered human fungal pathogen. This lifestyle is dependent on the ability of the fungus to undergo rapid genetic and epigenetic changes, often in response to specific environmental cues. A parasexual cycle in C. albicans has been defined that includes several unique properties when compared to the related model yeast, Saccharomyces cerevisiae. Novel features include strict regulation of mating via a phenotypic switch, enhanced conjugation within a sexual biofilm, and a program of concerted chromosome loss in place of a conventional meiosis. It is expected that several of these adaptations co-evolved with the ability of C. albicans to colonize the mammalian host.