Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein.
Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein.
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发表时间：
2000-06
期刊：
影响因子：
11.2
通讯作者：
G. Doyle;J. Bourdeau-Heller;S. Coulthard;L. Meisner;J. Ross
中科院分区：
文献类型：
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作者：
G. Doyle;J. Bourdeau-Heller;S. Coulthard;L. Meisner;J. Ross
编码区决定簇结合蛋白（CRD-BP）在体外与c-myc mRNA结合，被认为可稳定mRNA并增加c-Myc蛋白丰度。CRD-BP基因有15个外显子和14个内含子，是单拷贝的，位于小鼠的11号染色体和人类的17号染色体上，接近HER-2/neu。CRD-BP基因在40例人类乳腺癌中的12例中中度扩增;在另外2例中高度扩增（14.4和20个拷贝）。尽管它们很接近，但CRD-BP和HER-2/neu基因可以独立扩增。一种可能上调c-Myc丰度的基因的扩增可能会加速乳腺癌的发生。
The coding region determinant-binding protein (CRD-BP) binds in vitro to c-myc mRNA and is thought to stabilize the mRNA and increase c-Myc protein abundance. The CRD-BP gene has 15 exons and 14 introns, is single-copy, and is located on chromosome 11 in mice and 17 in humans, close to HER-2/neu. The CRD-BP gene is moderately amplified in 12 of 40 human breast cancers; it is highly amplified in 2 others (14.4 and 20 copies). Despite their proximity, CRD-BP and HER-2/neu genes can be amplified independently. Amplification of a gene that might up-regulate c-Myc abundance could accelerate breast cancer.