A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling.
A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling.
复制标题
DOI：
10.1038/srep31716
复制
发表时间：
2016-08-19
影响因子：
4.6
通讯作者：
Zhao H
中科院分区：
文献类型：
--
作者：
Wu L;Xu Q;Zhang H;Li M;Zhu C;Jiang M;Sang X;Zhao Y;Sun Q;Zhao H
雌激素受体信号在哺乳动物的多种生理过程中起着重要的调节作用。雌激素受体（ER）表达和/或其相关信号通路的失调与乳腺癌的发生、进展、转移和内分泌抵抗密切相关。非编码转录物是几乎所有基因调控水平的重要调控因子。然而，与雌激素受体信号通路相关的长非编码转录物（lncRNA）很少被充分描述。我们使用基于阵列的方法来鉴定33个雌激素受体激动相关（ERAR）lncRNA。编码-非编码基因共表达网络分析表明，15个ERARlncRNA与有丝分裂、DNA损伤和DNA修复相关。Kaplan-Meier分析表明，使用随机森林-递归特征消除算法选择的五种ESAR lncRNA与无内分泌耐药生存期、无远处转移生存期以及无疾病生存期显着相关。我们的研究结果表明，ERARlncRNAs可能作为指导乳腺癌治疗和预后的新生物标志物。此外，我们的研究结果揭示了一个新的途径，雌激素受体信号可以进一步探索。
Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition, and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding–non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage, and DNA repair. Kaplan–Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored.