Regulation of Energy Homeostasis and Health Consequences in Obesity
Regulation of Energy Homeostasis and Health Consequences in Obesity
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DOI：
10.1016/j.amjmed.2009.01.003
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发表时间：
2009-04-01
影响因子：
5.9
通讯作者：
Woodworth, Kristina A.
中科院分区：
文献类型：
--
作者：
Korner, Judith;Woods, Stephen C.;Woodworth, Kristina A.
人们日益意识到肥胖流行是一个严重的健康问题，这促使人们研究肥胖的能量稳态和病理生理学机制。食物摄入、能量消耗和脂肪储存都受到复杂的神经内分泌系统的调节。现在已经认识到，除了中枢神经体液通路外，脂肪组织还具有独立的内分泌功能，有助于能量稳态。此外，脂肪组织产生的炎症作用与肥胖相关的最重要的健康问题有关，包括心血管疾病和2型糖尿病，每一种疾病都有可能导致长期发病率和死亡风险增加。这种脂肪组织的炎症效应在腹型肥胖症中更为明显，这反映在腹型肥胖症患者心脏代谢风险的增加上。脂肪组织对能量稳态和炎症的内分泌影响突出了肥胖，特别是腹型肥胖对健康的关键影响，以及在临床实践中有效预防和管理策略的重要性。(C)2009 Elsevier Inc.保留所有权利。《美国医学杂志》(2009)122，S12-S18
The growing awareness of the obesity epidemic as a critical matter of health concern has prompted research into the mechanisms underlying energy homeostasis and the pathophysiology of obesity. Food intake, energy expenditure, and fat storage all are regulated by a complex neuroendocrine system. It is now recognized that in addition to central neurohumoral pathways, adipose tissue has an independent endocrine function that contributes to energy homeostasis. Moreover, adipose tissue exerts inflammatory effects that are linked to the most important health problems associated with obesity, including cardiovascular disease and type 2 diabetes mellitus, each of which has the potential to confer long-term morbidity and increased mortality risks. This inflammatory effect of adipose tissue is more pronounced in abdominal obesity, which is reflected by the heightened cardiometabolic risk observed in persons with excess abdominal adiposity. The endocrine impact of adipose tissue on energy homeostasis and inflammation highlights the critical health implications of obesity, particularly abdominal obesity, and the importance of effective prevention and management strategies in clinical practice. (C) 2009 Elsevier Inc. All rights reserved. The American Journal of Medicine (2009) 122, S12-S18