Pannexin channel and connexin hemichannel expression in vascular function and inflammation.
Pannexin channel and connexin hemichannel expression in vascular function and inflammation.
复制标题
血管功能和炎症中的Pannexin通道和连接性半通道表达。
DOI：
10.1186/s12860-016-0119-3
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发表时间：
2017-01-17
期刊：
影响因子：
--
通讯作者：
Figueroa XF
中科院分区：
文献类型：
--
作者：
Begandt D;Good ME;Keller AS;DeLalio LJ;Rowley C;Isakson BE;Figueroa XF
血流分布和组织稳态的控制依赖于微血管网络和循环血细胞之间的紧密调节和协调。由连接蛋白或泛连接蛋白形成的通道连接细胞内和细胞外区室，允许释放旁分泌信号，如ATP和前列腺素，从而在实现血管功能的精细调节和协调中发挥核心作用。本文主要综述了血管连接蛋白半通道和全通道。我们回顾了它们在动脉和静脉系统中的表达模式，特别强调了这些通道的磷酸化和s -亚硝基化是如何通过翻译后修饰来调节它们的功能并促进血管稳态的。此外，我们强调平滑肌细胞和内皮细胞中的这些通道在调节血管舒缩张力中的作用，以及内皮细胞中的这些通道如何调节缺血和缺氧条件下的炎症反应。此外，这篇综述将触及最近的证据暗示这些蛋白在调节红细胞和血小板功能中的作用。
Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins or pannexins that connect the intra- and extracellular compartments allow the release of paracrine signals, such as ATP and prostaglandins, and thus play a central role in achieving fine regulation and coordination of vascular function. This review focuses on vascular connexin hemichannels and pannexin channels. We review their expression pattern within the arterial and venous system with a special emphasis on how post-translational modifications by phosphorylation and S-nitrosylation of these channels modulate their function and contribute to vascular homeostasis. Furthermore, we highlight the contribution of these channels in smooth muscle cells and endothelial cells in the regulation of vasomotor tone as well as how these channels in endothelial cells regulate inflammatory responses such as during ischemic and hypoxic conditions. In addition, this review will touch on recent evidence implicating a role for these proteins in regulating red blood cell and platelet function.
DOI：
10.1111/j.1538-7836.2007.02525.x
发表时间：
2007-05
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
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作者：
Fung CY;Cendana C;Farndale RW;Mahaut-Smith MP
通讯作者：
Mahaut-Smith MP