Effects of multiple occupancy and interparticle interactions on selective transport through narrow channels: theory versus experiment.
Effects of multiple occupancy and interparticle interactions on selective transport through narrow channels: theory versus experiment.
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DOI：
10.1016/j.bpj.2008.09.058
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发表时间：
2008-11
影响因子：
3.4
通讯作者：
A. Zilman
中科院分区：
文献类型：
--
作者：
A. Zilman
许多生物和人工转运通道在转运过程中没有代谢能的直接输入，也没有涉及从封闭状态到开放状态转变的结构重排。然而，这样的通道能够保持高效和选择性的传输。已经提出，运输分子和通道之间的吸引力相互作用可以提高运输效率，并且此类通道的选择性可以基于特异性运输分子与通道相互作用的强度。在这里，我们研究了通过窄通道的一般动力学理论的框架，它自然包括多粒子占用的通道和非单行运输的运输。我们研究了如何通过通道的运输效率和易位的概率的影响，在通道内的有限空间中的粒子间的相互作用，并建立选择性运输的条件。我们比较了模型的预测与现有的实验数据，发现良好的半定量协议。最后，我们讨论了该理论在人工纳米分子筛设计中的应用。
Many biological and artificial transport channels function without direct input of metabolic energy during a transport event and without structural rearrangements involving transitions from a closed to an open state. Nevertheless, such channels are able to maintain efficient and selective transport. It has been proposed that attractive interactions between the transported molecules and the channel can increase the transport efficiency and that the selectivity of such channels can be based on the strength of the interaction of the specifically transported molecules with the channel. Herein, we study the transport through narrow channels in a framework of a general kinetic theory, which naturally incorporates multiparticle occupancy of the channel and non-single-file transport. We study how the transport efficiency and the probability of translocation through the channel are affected by interparticle interactions in the confined space inside the channel, and establish conditions for selective transport. We compare the predictions of the model with the available experimental data and find good semiquantitative agreement. Finally, we discuss applications of the theory to the design of artificial nanomolecular sieves.