Neuropeptide and cardiovascular responses to intravenous catheterization in normotensive and hypertensive blacks and whites.
Neuropeptide and cardiovascular responses to intravenous catheterization in normotensive and hypertensive blacks and whites.
复制标题
血压正常和高血压的黑人和白人对静脉插管的神经肽和心血管反应。
DOI：
10.1037//0278-6133.8.5.487
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Zeichner,A
中科院分区：
文献类型：
--
作者：
McNeilly,M;Zeichner,A
研究表明，对压力源的心血管和神经内分泌（通常是儿茶酚胺）反应升高可能导致高血压的发展，并且可能存在潜在致病性的反应模式的种族差异。某些神经肽对血压（BP）和心率（HR）产生深远的影响，但没有发表的研究已经检查了这些肽，高血压状态，种族和反应之间的关系。17名黑人和20名白色血压正常和边缘高血压的男性19- 50岁的人进行了静脉导管插入术，同时检查了心血管和神经肽对导管插入应激的反应。结果表明，在响应的压力，黑色高血压患者显示出显着较低的内啡肽水平相比，黑色血压正常，和白色高血压患者显示出显着较高的β内啡肽水平相比，白色血压正常。各组在恢复时的内啡肽水平无显著差异。与白色高血压患者和血压正常者相比，黑人高血压患者也显示出显著更高的应激诱导的HR和收缩压和舒张压。较低的β-内啡肽水平和较低的尿钠排泄量与较高的血压和心率相关。
Research suggests that heightened cardiovascular and neuroendocrine (typically catecholamine) responses to stressors may lead to the development of hypertension and that there may be race differences in patterns of reactivity that are potentially pathogenic. Certain neuropeptides exert profound effects on blood pressure (BP) and heart rate (HR), yet no published studies have examined relationships between these peptides, hypertensive status, race, and reactivity. Seventeen Black and 20 White normotensive and borderline-hypertensive male 19-to 50-year-olds underwent intravenous catheterization while cardiovascular and neuropeptide responses to the stress of being catheterized were examined. Results indicate that, in response to the stressor, Black hypertensives showed significantly lower endorphin levels compared to Black normotensives, and White hypertensives showed significantly higher levels of betaendorphin compared to White normotensives. Groups were not significantly different in endorphin levels at recovery. Black hypertensives also showed significantly higher stressor-induced HR and systolic and diastolic BP compared to White hypertensives and normotensives. Lower levels of beta-endorphin and lower urine sodium excretion were associated with higher BP and HR.