Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm.
Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm.
复制标题
鉴定精子中 Ras 2 mRNA 的截短激酶抑制因子。
DOI：
10.1016/j.fob.2014.04.004
复制
发表时间：
2014
期刊：
影响因子：
2.6
通讯作者：
Lewis,RobertE
中科院分区：
文献类型：
--
作者：
Guo,Lili;Volle,DeannaJ;Lewis,RobertE
The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germlinempk-1(Caenorhabditis elegansERK) phosphorylation inC. elegansand has been implicated the regulation of meiosis. KSR2−/−mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility.
