Effect of heparin on platelet aggregation
Effect of heparin on platelet aggregation
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肝素对血小板聚集的影响
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
G. Morelli
中科院分区：
文献类型：
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作者：
H. Saba;S. Saba;G. Morelli
在血浆中血小板（PRP）以及凝胶过滤、洗涤和甲醛固定的血小板上系统检查了肝素对血小板聚集的影响。结果表明，虽然肝素导致PRP系统中血小板聚集的轻度增强，但当肝素加入到分离的血小板中时，观察到显著的抑制活性。这种抑制活性似乎具有特异性，与肝素制剂中的杂质无关，因为肝素酶以及鱼精蛋白可有效中和肝素介导的血小板聚集抑制活性。
The effect of heparin on platelet aggregation was systematically examined on platelets in plasma (PRP), as well as on gel‐filtered, washed, and formaldehyde‐fixed platelets. Results indicate that, although heparin causes a mild potentiation of platelet aggregation in the PRP systems, a significant inhibitory activity is observed when heparin is added to isolated platelets. This inhibitory activity appears to be specific and not related to the impurities in the heparin preparations, as heparinase, as well as protamine, effectively neutralizes the heparin‐mediated inhibitory activity on platelet aggregation.
肝素对血小板聚集和释放以及血栓素 A2 产生的影响。
DOI：
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发表时间：
1981
期刊：
The American journal of pathology
影响因子：
--
作者：
Mohammad,SF;Anderson,WH;Smith,JB;Chuang,HY;Mason,RG
通讯作者：
Mason,RG
出血性疾病患者血小板对血栓素 A2 的反应受损，钙动员缺陷。
影响因子：
20.3
作者：
Lages,B;Malmsten,C;Weiss,HJ;Samuelsson,B
通讯作者：
Samuelsson,B