Induction of colitis in mice (T-cell transfer model).
Induction of colitis in mice (T-cell transfer model).
复制标题
诱导小鼠结肠炎（T 细胞转移模型）。
DOI：
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发表时间：
2014
影响因子：
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通讯作者：
B. Weigmann
中科院分区：
文献类型：
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作者：
B. Weigmann
肠道炎症的动物模型对于了解克罗恩病和溃疡性结肠炎等炎症性肠病的病理机制至关重要。通常情况下，幼稚T细胞被转移到免疫功能低下的小鼠中，由于不适当的下调而发生肠道炎症。在这里，我们描述了分离，纯化，并转移到受体的CD 4（+）CD 25（-）T细胞，以获得一个实验性结肠炎模型的发病机制分析。
Animal model of intestinal inflammation is essential for the understanding of the pathomechanisms of inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Typically, naïve T-cells were transferred into immunocompromised mice and develop gut inflammation because of inappropriate downregulation. Here, we describe the isolation, purification, and transfer of CD4(+)CD25(-) T-cells into recipients to obtain an experimental colitis model for the analysis of pathogenesis.