The Prevalence of Vaginal Microorganisms in Pregnant Women with Preterm Labor and Preterm Birth
The Prevalence of Vaginal Microorganisms in Pregnant Women with Preterm Labor and Preterm Birth
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DOI：
10.3343/alm.2012.32.3.194
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发表时间：
2012-05-01
影响因子：
4.9
通讯作者：
Lee, Anna
中科院分区：
文献类型：
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作者：
Choi, Seong Jin;Park, Soon Deok;Lee, Anna
背景资料：为了调查发生早产（PTB）的妇女阴道感染的危险因素和阴道微生物的抗菌药物敏感性，我们比较了发生早产（PTL）但未发生早产的妇女和自发性PTB妇女阴道微生物的患病率。对126例发生PTL的孕妇的阴道拭子标本进行了B组链球菌（GBS）、人型支原体、生殖支原体、解脲脲原体、沙眼衣原体、阴道毛滴虫、淋病奈瑟菌、梅毒螺旋体、单纯疱疹病毒（HSV）I和II和细菌性阴道病。对照组91名孕妇进行了GBS测试。对GBS、M. hominis和U.结果：各微生物的总检出率分别为：U.解脲支原体62.7%;人型占12.7%，GBS占7.9%，C.单纯疱疹病毒Ⅱ型占0.8%。对照组GBS定植率为17.6%。GBS、M. hominis和U.无早产的PTL组和自发性PTB组的解脲支原体感染率分别为3.8%和8.7%（相对危险度[RR]，2.26），3.8%和17.3%（RR，4.52），53.8%和60.9%（RR，1.13），两组间差异无统计学意义。M. PCR法检测人型的阳性率高于培养法（11.1%vs.4.0%，P= 0.010）。U. PCR法和培养法检测结果分别为16.7%和57.1%。hominis和U.自发性PTB和PTL无早产组之间的解脲支原体。
Background: To investigate the risk factors for vaginal infections and antimicrobial susceptibilities of vaginal microorganisms among women who experienced preterm birth (PTB), we compared the prevalence of vaginal microorganisms between women who experienced preterm labor (PTL) without preterm delivery and spontaneous PTB.Methods: Vaginal swab specimens from 126 pregnant women who experienced PTL were tested for group B streptococcus (GBS), Mycoplasma hominis, Mycoplasma genitalium, Urea plasma urealyticum, Chlamydia trachomatis, Trichomonas vaginalis, Neisseria gonorrhoeae, Treponema pallidum, herpes simplex virus (HSV) I and II, and bacterial vaginosis. A control group of 91 pregnant women was tested for GBS. Antimicrobial susceptibility tests were performed for GBS, M. hominis, and U. urealyticum.Results: The overall detection rates for each microorganism were: U. urealyticum, 62.7%; M. hominis, 12.7%; GBS, 7.9%; C. trachomatis, 2.4%; and HSV type II, 0.8%. The colonization rate of GBS in control group was 17.6%. The prevalence of GBS, M. hominis, and U. urealyticum in PTL without preterm delivery and spontaneous PTB were 3.8% and 8.7% (relative risk [RR], 2.26), 3.8% and 17.3% (RR, 4.52), and 53.8% and 60.9% (RR, 1.13), respectively, showing no significant difference between the 2 groups. The detection rate of M. hominis by PCR was higher than that by culture method (11.1% vs. 4.0%, P= 0.010). The detection rates of U. urealyticum by PCR and culture method were 16.7% and 57.1%, respectively.Conclusions: There was no significant difference in the prevalence of GBS, M. hominis, and U. urealyticum between the spontaneous PTB and PTL without preterm delivery groups.