The p53-MDM2 network: from oscillations to apoptosis
The p53-MDM2 network: from oscillations to apoptosis
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DOI：
10.1007/s12038-007-0103-3
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发表时间：
2007-08-01
影响因子：
2.9
通讯作者：
Ghosh, Bhaswar
中科院分区：
文献类型：
--
作者：
Bose, Indrani;Ghosh, Bhaswar
p53蛋白以其肿瘤抑制功能而闻名。p53-MDM 2负反馈环构成了在细胞应激下激活的调节相互作用网络的核心模块。在正常细胞中，p53蛋白的水平被MDM 2保持在低水平，即MDM 2负调节p53的活性。在DNA损伤的情况下，p53介导的途径被激活，导致细胞周期停滞和DNA修复。如果由于过度损伤而无法修复，则p53介导的凋亡途径被激活，导致细胞死亡。本文从系统生物学的角度对p53-MDM 2模块及其相关通路的研究进行了综述。我们讨论了一些关键的预测，涉及到细胞周期停滞和细胞死亡的一些具体方面，这可以在实验中进行测试。
The p53 protein is well-known for its tumour suppressor function. The p53-MDM2 negative feedback loop constitutes the core module of a network of regulatory interactions activated under cellular stress. In normal cells, the level of p53 proteins is kept low by MDM2, i.e. MDM2 negatively regulates the activity of p53. In the case of DNA damage, the p53-mediated pathways are activated leading to cell cycle arrest and repair of the DNA. If repair is not possible due to excessive damage, the p53-mediated apoptotic pathway is activated bringing about cell death. In this paper, we give an overview of our studies on the p53-MDM2 module and the associated pathways from a systems biology perspective. We discuss a number of key predictions, related to some specific aspects of cell cycle arrest and cell death, which could be tested in experiments.