Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report
Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report
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DOI：
10.1016/j.burns.2004.04.010
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发表时间：
2004-12-01
期刊：
影响因子：
2.7
通讯作者：
Singer, AJ
中科院分区：
文献类型：
--
作者：
Rosenberg, L;Lapid, O;Singer, AJ
一项前瞻性的非对比研究设计被用来描述我们在1984-1999年间治疗的130例患者中使用菠萝酶来源的清创剂清创剂的经验，这些患者有332例深二度和三度烧伤。用湿敷料浸泡创面2-24小时后使用脱毛酶。在封闭敷料下应用脱毛酶4小时。患者平均年龄为18.6±19.3岁。女性42例，占32.3%。其中63例(48.5%)为18岁以下儿童，多数为小面积烧伤。332个创面中使用清创酶1次241例(72.6%)，2次67例(20.18%)，3次12例(3.61%)，4次2例(0.6%)。按申请数目划分的清创百分比分别为：单一申请+/-21%、两项申请+/-27%及三项申请+/-27%。没有发生明显的不良反应。一种快速、可靠、无并发症的酶清理剂的出现可能会开辟新的视野，为烧伤提供一种新的治疗方式。(C)2004年爱思唯尔有限公司和ISBI。版权所有。
A prospective, non-comparative study design was used to describe our experience with a bromelain-derived debriding agent, Debridase, in 130 patients with 332 deep second degree and third degree burns treated between 1984 and 1999. Debridase was applied after saturating the bums with a moist dressing for 2-24 h. Debridase was applied for a period of 4 h under an occlusive dressing. Mean patient age was 18.6 +/- 19.3. 42(32.3%) were female. and 63(48.5%) were children under age 18. Most burns were small. Debridase was applied once in 241(72.6%) of the 332 wounds, twice in 67 (20.18%) cases, three times in 12(3.61 %) cases, and four times in 2(0.6%) cases. The percentage debridement by number of applications was 89 +/- 21 % for a single application, 77 +/- 27% for two, and 62 27% for three Debridase applications, respectively. There were no significant adverse events. The availability of a fast acting, reliable and complication-free enzymatic debriding agent may open new horizons and provide a new treatment modality for burns. (C) 2004 Elsevier Ltd and ISBI. All rights reserved.