In vitro anti-HIV and Cytotoxicological Evaluation of the Triple Combination: AZT and ddC with HIV Proteinase Inhibitor Saquinavir (Ro 31-8959)
In vitro anti-HIV and Cytotoxicological Evaluation of the Triple Combination: AZT and ddC with HIV Proteinase Inhibitor Saquinavir (Ro 31-8959)
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三重组合的体外抗 HIV 和细胞毒理学评价：AZT 和 ddC 与 HIV 蛋白酶抑制剂沙奎那韦 (Ro 31-8959)
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
N. Roberts
中科院分区：
文献类型：
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作者：
J. Craig;L. Whittaker;I. Duncan;N. Roberts
已经在体外研究了三种抗HIV化合物（AZT、ddC和沙奎那韦）的组合。在先前研究的确认和扩展中，当任何两种化合物组合时，发现对HIV-1GB 8和HIV-1 N1 T的加和效应大于加和效应。当所有三种化合物一起使用时，还发现对两种病毒株的协同作用。细胞毒理学研究表明，这种治疗可以维持高治疗指数。改善抗艾滋病毒监测的潜在益处，降低对治疗产生耐药性的风险，减少对产生毒副作用的药物的需求，支持延长沙奎那韦的临床试验，以研究这种组合。
A combination of three anti-HIV compounds (AZT, ddC and saquinavir) has been studied in vitro. In confirmation and extension of previous studies, a greater than additive effect was found against both HIV-1GB8 and HIV-1N1T, when any two compounds were combined. Synergy of action was also found against both virus strains when all three compounds were employed together. Cytotoxicological studies indicated that a high therapeutic index could be maintained for this treatment. The potential benefits of improved anti-HIV surveillance, reduced risk of the development of resistance to the treatment and reduced requirement for drugs in quantities that produce toxic side-effects support the extension of clinical trials of saquinavir to investigate this combination.
影响因子：
56.9
作者：
KOHLSTAEDT, LA;WANG, J;STEITZ, TA
通讯作者：
STEITZ, TA
2,3-二脱氧胞苷的细胞代谢，一种在体外具有抗人类免疫缺陷病毒活性的化合物。
DOI：
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发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Starnes,MC;Cheng,YC
通讯作者：
Cheng,YC