Fetal programming of body dimensions and percentage body fat measured in prepubertal children with a 4-component model of body composition, dual-energy X-ray absorptiometry, deuterium dilution, densitometry, and skinfold thicknesses
Fetal programming of body dimensions and percentage body fat measured in prepubertal children with a 4-component model of body composition, dual-energy X-ray absorptiometry, deuterium dilution, densitometry, and skinfold thicknesses
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DOI：
10.1093/ajcn/86.3.618
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发表时间：
2007-09-01
影响因子：
7.1
通讯作者：
Mulligan, Jean
中科院分区：
文献类型：
--
作者：
Elia, Marinos;Betts, Peter;Mulligan, Jean
背景资料：子宫内编程的身体成分[体脂百分比（%BF）]已稀疏检查与多个独立的参考技术在儿童。体型（尺寸、质量和身体各部分的长度）的影响和后果尚不清楚。目的：本研究探讨青春期前儿童的脂肪百分比和脂肪百分比与体重指数（BMI;单位：kg/m2）的关系是否在宫内发育过程中被编程并依赖于体型。本研究的目的还在于检验父母身高和出生体重在多大程度上可以预测身高。设计：85名白色儿童（44名男孩，41名女孩;年龄6.5-9.1岁），采用4组分模型（n = 58）、双能X射线吸收测定法（n = 84）、氘稀释法（n = 81）、密度测定法（n = 62），结果：出生体重每增加1 SD，四分量模型测得的脂肪减少1.95%（P = 0.012），其他方法测得的脂肪减少0.82-2.75%。这些关联与年龄、性别、社会经济地位、身体活动、BMI和体型无关。体型并没有降低这种联系的强度。出生体重是一个比自我报告的双亲身高更好的身高预测因子，在5岁时占19.4%，在7.8岁时占10.3%（其中17.8%和8.8%在这些年龄段与父母身高无关）。身体组成测量技术的一致趋势增加了青春期前儿童脂肪百分比在子宫内编程（独立于身体构造和BMI）的建议。它还表明，出生体重是一个更好的预测青春期前的身高比自我报告的中期父母的身高。
Background: Intrauterine programming of body composition [percentage body fat (%BF)] has been sparsely examined with multiple independent reference techniques in children. The effects on and consequences of body build (dimensions, mass, and length of body segments) are unclear.Objective: The study examined whether percentage fat and relation of percentage fat to body mass index (BMI; in kg/m(2)) in prepubertal children are programmed during intrauterine development and are dependent on body build. It also aimed to examine the extent to which height can be predicted by parental height and birth weight.Design: Eighty-five white children (44 boys, 41 girls; aged 6.5-9.1 y) had body composition measured with a 4-component model (n = 58), dual-energy X-ray absorptiometry (n = 84), deuterium dilution (n = 81), densitometry (n = 62), and skinfold thicknesses (n = 85).Results: An increase in birth weight of 1 SD was associated with a decrease of 1.95% fat as measured by the 4-component model (P = 0.012) and 0.82-2.75% by the other techniques. These associations were independent of age, sex, socioeconomic status, physical activity, BMI, and body build. Body build did not decrease the strength of the associations. Birth weight was a significantly better predictor of height than was self-reported midparental height, accounting for 19.4% of the variability at 5 y of age and 10.3% at 7.8 y of age (17.8% and 8.8% of which were independent of parental height at these ages, respectively).Conclusions: Consistent trends across body-composition measurement techniques add strength to the suggestion that percentage fat in prepubertal children is programmed in utero (independently of body build and BMI). It also suggests birth weight is a better predictor of prepubertal height than is self-reported midparental height.