Optical trapping and manipulation for single-particle spectroscopy and microscopy
Optical trapping and manipulation for single-particle spectroscopy and microscopy
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DOI：
10.1063/5.0086328
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发表时间：
2022-08-07
影响因子：
4.4
通讯作者：
Yan, Zijie
中科院分区：
文献类型：
--
作者：
Chen, Zhenzhen;Cai, Zhewei;Yan, Zijie
光镊可以控制溶液中单个胶体颗粒的位置和方向。这种控制通常是可取的，但对于单粒子光谱学和显微镜学来说却具有挑战性，特别是在纳米尺度上。在三维（3D）空间中进行光学捕获和操纵的功能纳米颗粒可以作为独立的纳米探针，为传感和绘制纳米颗粒周围环境以及研究它们与生物系统的相互作用提供独特的前景。从这个角度来看，我们将首先描述光学捕获和操纵微观粒子的光学力，然后回顾不同光谱和显微镜技术与光镊的组合和应用。最后，我们将讨论使用光镊对单个纳米颗粒进行光谱和显微镜检查的挑战、解决这些挑战的可能途径以及将出现的新机遇。由 AIP Publishing 独家许可出版。
Optical tweezers can control the position and orientation of individual colloidal particles in solution. Such control is often desirable but challenging for single-particle spectroscopy and microscopy, especially at the nanoscale. Functional nanoparticles that are optically trapped and manipulated in a three-dimensional (3D) space can serve as freestanding nanoprobes, which provide unique prospects for sensing and mapping the surrounding environment of the nanoparticles and studying their interactions with biological systems. In this perspective, we will first describe the optical forces underlying the optical trapping and manipulation of microscopic particles, then review the combinations and applications of different spectroscopy and microscopy techniques with optical tweezers. Finally, we will discuss the challenges of performing spectroscopy and microscopy on single nanoparticles with optical tweezers, the possible routes to address these challenges, and the new opportunities that will arise. Published under an exclusive license by AIP Publishing.