An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.
An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.
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DOI：
10.1007/978-1-4939-3670-0_19
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Bai F
中科院分区：
文献类型：
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作者：
Acharya D;Bai F
西尼罗河病毒（WNV）感染自1999年出现以来在美国各地持续存在，并在地球仪各地持续传播，迫切需要有效的治疗和预防措施。虽然几种西尼罗河病毒疫苗的兽医使用许可证提供了一个概念的证明，类似的努力，为人类开发一种有效的疫苗仍然没有成功。随着对西尼罗河病毒生物学和发病机制的了解的增加，以及最近的技术进步，人们对在不久的将来可能获得有效的西尼罗河病毒疫苗产生了希望。此外，WNV和其他黄病毒蛋白的结构和功能表征的快速进展为设计和开发几类抑制剂作为潜在的WNV治疗剂提供了坚实的基础。此外，治疗性单克隆抗体在动物模型中显示出针对WNV的优异功效，并且代表了一类有前途的WNV治疗剂。然而，在设计和开发安全有效的西尼罗河病毒疫苗或治疗剂方面存在一些挑战。在这一章中，我们讨论了目前的方法，进展和挑战对西尼罗河病毒疫苗，治疗性抗体和抗病毒药物的发展。
The persistence of West Nile virus (WNV) infections throughout the USA since its inception in 1999 and its continuous spread throughout the globe calls for an urgent need of effective treatments and prevention measures. Although the licensing of several WNV vaccines for veterinary use provides a proof of concept, similar efforts on the development of an effective vaccine for humans remain still unsuccessful. Increased understanding of biology and pathogenesis of WNV together with recent technological advancements have raised hope that an effective WNV vaccine may be available in the near future. In addition, rapid progress in the structural and functional characterization of WNV and other flaviviral proteins have provided a solid base for the design and development of several classes of inhibitors as potential WNV therapeutics. Moreover, the therapeutic monoclonal antibodies demonstrate an excellent efficacy against WNV in animal models and represent a promising class of WNV therapeutics. However, there are some challenges as to the design and development of a safe and efficient WNV vaccine or therapeutic. In this chapter, we discuss the current approaches, progress, and challenges toward the development of WNV vaccines, therapeutic antibodies, and antiviral drugs.