Sleep-Disordered Breathing Is a Stronger Risk Factor for Proliferative Diabetic Retinopathy than Metabolic Syndrome and the Number of Its Individual Components
Sleep-Disordered Breathing Is a Stronger Risk Factor for Proliferative Diabetic Retinopathy than Metabolic Syndrome and the Number of Its Individual Components
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DOI：
10.1080/08820538.2019.1569074
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发表时间：
2019-02-17
影响因子：
1.7
通讯作者：
Hori, Yuichi
中科院分区：
文献类型：
--
作者：
Shiba, Tomoaki;Takahashi, Mao;Hori, Yuichi
目的：评估与代谢综合征（MetS）的发病率及其单个组分的数量相比，睡眠呼吸障碍（SDB）的特征是否是增殖性糖尿病视网膜病变（PDR）的更强的独立因素。方法：我们对132例2型糖尿病患者进行了横断面研究。39例患者患有非增殖性糖尿病视网膜病变（NPDR），93例患者患有PDR。进行脉搏血氧测定，并评估患者的平均血氧饱和度（平均SpO2%）和4%氧减饱和指数（4%ODI次数/小时）。我们比较了NPDR和PDR患者之间的SDB和MetS变量。Logistic回归分析用于确定PDR诊断的独立因素。结果：MetS诊断在PDR组中显著更常见（p = 0.04）。PDR组中单个MetS组分的数量显著高于NPDR组（p = 0.01）。NPDR组的平均SpO 2与PDR组无显著差异。NPDR组的4%ODI显著低于PDR组（p = 0.01）。Logistic回归分析显示，年龄小、4%ODI值高是影响PDR诊断的独立因素。结论：我们的研究结果证实，与MetS及其单个组分的数量相比，SDB可能是导致PDR进展的一个因素。然而，需要进一步仔细的纵向验证研究。
Purpose: To evaluate whether the features of sleep-disordered breathing (SDB) are stronger independent factors for proliferative diabetic retinopathy (PDR) compared to the incidence of metabolic syndrome (MetS) and the number of its individual components. Methods: We studied a cross-sectional total of 132 patients with type 2 diabetes. Thirty-nine patients had non-proliferative diabetic retinopathy (NPDR) and 93 patients had PDR. Pulse oximetry was conducted, and the patients' mean oxygen saturation (mean SpO2%) and 4% oxygen desaturation index (4% ODI times/hour) were evaluated. We compared the SDB and MetS variables between the NPDR and PDR patients. A logistic regression analysis was used to determine the independent factors for the diagnosis of PDR. Results: The MetS diagnosis was made significantly more often in the PDR group (p = 0.04). The number of individual MetS components was significantly greater in the PDR group compared to the NPDR group (p = 0.01). The mean SpO2 of the NPDR group was not significantly different from that of the PDR group. The 4% ODI in the NPDR group was significantly lower than that in the PDR group (p = 0.01). The logistic regression analysis using the prevalence of MetS and the number of MetS components revealed that younger age and high 4%ODI value were independent factors contributing to the diagnosis of PDR. Conclusion: Our findings confirmed that compared to MetS and the number of its individual components, SDB may be a factor contributing to the progression to PDR. However, further careful longitudinal validation studies are needed.